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Seizure-protecting effects of kyotorphin and related peptides in an animal model of epilepsy.

Abstract
Administration of peptides kyotorphin (KT), neokyotorphin (NKT), and d-ser-2-NKT into the lateral brain ventricle (10 nmol) increased the latency and attenuated the severity of picrotoxin-induced convulsions in rats. Anticonvulsive effects of the peptides were also observed after their administration into the CA1 hippocampi (2.5, 5, 10 nmol), with the order of potency d-ser-2-NKT-->NKT-->KT. When injected into the substantia nigra reticulata, the 10 nmol dose of NKT and d-ser-2-NKT displayed equal seizure-protecting effect, which was higher than that for KT. It is concluded that kyotorphin and its analogs provide structure-dependent, dose-dependent, and target site-dependent antiepileptic effect.
AuthorsL S Godlevsky, A A Shandra, I I Mikhaleva, R S Vastyanov, A M Mazarati
JournalBrain research bulletin (Brain Res Bull) Vol. 37 Issue 3 Pg. 223-6 ( 1995) ISSN: 0361-9230 [Print] United States
PMID7627564 (Publication Type: Journal Article)
Chemical References
  • Analgesics
  • Anticonvulsants
  • Endorphins
  • kyotorphin
  • Picrotoxin
  • neo-kyotorphin
Topics
  • Analgesics (therapeutic use)
  • Animals
  • Anticonvulsants (therapeutic use)
  • Dose-Response Relationship, Drug
  • Endorphins (therapeutic use)
  • Hippocampus
  • Injections
  • Injections, Intraventricular
  • Male
  • Picrotoxin
  • Rats
  • Rats, Wistar
  • Seizures (chemically induced, prevention & control)
  • Stereoisomerism
  • Substantia Nigra

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