Abstract |
Administration of peptides kyotorphin (KT), neokyotorphin (NKT), and d-ser-2-NKT into the lateral brain ventricle (10 nmol) increased the latency and attenuated the severity of picrotoxin-induced convulsions in rats. Anticonvulsive effects of the peptides were also observed after their administration into the CA1 hippocampi (2.5, 5, 10 nmol), with the order of potency d-ser-2-NKT-->NKT-->KT. When injected into the substantia nigra reticulata, the 10 nmol dose of NKT and d-ser-2-NKT displayed equal seizure-protecting effect, which was higher than that for KT. It is concluded that kyotorphin and its analogs provide structure-dependent, dose-dependent, and target site-dependent antiepileptic effect.
|
Authors | L S Godlevsky, A A Shandra, I I Mikhaleva, R S Vastyanov, A M Mazarati |
Journal | Brain research bulletin
(Brain Res Bull)
Vol. 37
Issue 3
Pg. 223-6
( 1995)
ISSN: 0361-9230 [Print] United States |
PMID | 7627564
(Publication Type: Journal Article)
|
Chemical References |
- Analgesics
- Anticonvulsants
- Endorphins
- kyotorphin
- Picrotoxin
- neo-kyotorphin
|
Topics |
- Analgesics
(therapeutic use)
- Animals
- Anticonvulsants
(therapeutic use)
- Dose-Response Relationship, Drug
- Endorphins
(therapeutic use)
- Hippocampus
- Injections
- Injections, Intraventricular
- Male
- Picrotoxin
- Rats
- Rats, Wistar
- Seizures
(chemically induced, prevention & control)
- Stereoisomerism
- Substantia Nigra
|