HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[New approaches to the treatment of nephritis].

Abstract
The paper provides evidence and results of using new therapeutical treatment of glomerulonephritis, such as pulse-therapy with cyclophosphane, therapy with angiotension-converting enzyme (ACE) inhibitors or that with antihyperlipidemic agents. Based on much experience with pulse-therapy with cyclophosphane (over 100 patients with chronic glomerulonephritis (CGN) and lupus nephritis), it is concluded that this method is highly effective. Treating 57 patients with ACE inhibitors has shown that in CGN these drugs should be used only when taking into account their antihypertensive effect and capacity of lowering intraglomerular hypertension, as evidenced by the renal functional reserve, and diminishing proteinuria. The long-term (7-12 month) antihyperlipidemic therapy (diet and lovastatin) in 20 patients with CGN accompanied by the nephrotic syndrome caused a significant reduction in the concentration of serum cholesterol and proteinuria, a significant increase in serum albumin levels; remission of the nephrotic syndrome occurred in 9 patients; but better effects were observed in non-inflammatory nephropathies, such as membranous nephropathy, focal segmental glomerulosclerosis, and nephrosclerosis.
AuthorsI E Tareeva
JournalVestnik Rossiiskoi akademii meditsinskikh nauk (Vestn Ross Akad Med Nauk) Issue 5 Pg. 52-6 ( 1995) ISSN: 0869-6047 [Print] Russia (Federation)
Vernacular TitleNovye podkhody k lecheniiu nefritov.
PMID7626987 (Publication Type: Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Cyclophosphamide
  • Lovastatin
  • Peptidyl-Dipeptidase A
Topics
  • Animals
  • Cells, Cultured
  • Chronic Disease
  • Cyclophosphamide (therapeutic use)
  • Glomerulonephritis (diet therapy, drug therapy)
  • Humans
  • Lovastatin (therapeutic use)
  • Lupus Nephritis (diet therapy, drug therapy)
  • Mice
  • Nephritis (diet therapy, drug therapy)
  • Nephrosclerosis (diet therapy, drug therapy)
  • Nephrotic Syndrome (diet therapy, drug therapy)
  • Peptidyl-Dipeptidase A (therapeutic use)
  • Rats
  • Rats, Wistar
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: