Abstract |
The activities of sparfloxacin, levofloxacin, Bay y 3118, azithromycin, cefprozil, loracarbef, and nine other oral antimicrobial agents against 194 aerobic and anaerobic clinical bite wound isolates were determined by the agar dilution method. Sparfloxacin, levofloxacin, and Bay y 3118 were active against all aerobic isolates (MICs at which 90% of the isolates are inhibited [MIC90], < or = 1.0 microgram/ml for sparfloxacin and levofloxacin and 0.1 microgram/ml for Bay y 3118) and many anaerobic isolates, with the exception of the fusobacteria. Azithromycin was more active than erythromycin by 1 to 2 dilutions against many aerobes, including Pasteurella multocida and Eikenella corrodens, and by 2 to 4 dilutions against anaerobic isolates. Cefprozil was more active (MIC90, < or = 1 microgram/ml) than loracarbef (MIC90, < or = 4 micrograms/ml) against aerobic gram-positive isolates, but both had poor activity (MIC90, > or = 16 micrograms/ml) against peptostreptococci. Both cefprozil and loracarbef had MIC90s of < or = 0.5 micrograms/ml against P. multocida.
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Authors | E J Goldstein, C A Nesbit, D M Citron |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 39
Issue 5
Pg. 1097-100
(May 1995)
ISSN: 0066-4804 [Print] United States |
PMID | 7625795
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Infective Agents
- Fluoroquinolones
- Quinolones
- Bay Y3118
- Levofloxacin
- Azithromycin
- Ofloxacin
- sparfloxacin
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Topics |
- Anti-Bacterial Agents
(pharmacology)
- Anti-Infective Agents
(pharmacology)
- Azithromycin
(pharmacology)
- Bacteria, Aerobic
(drug effects)
- Bacteria, Anaerobic
(drug effects)
- Bites and Stings
(complications)
- Bites, Human
(complications)
- Fluoroquinolones
- Humans
- Levofloxacin
- Microbial Sensitivity Tests
- Ofloxacin
(pharmacology)
- Quinolones
(pharmacology)
- Wound Infection
(microbiology)
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