Abstract |
beta-Hexosaminidase B- isoforms ( beta-hexosaminidase B, P, and intermediate forms; abbreviated herein as " Hex B") and serum carbohydrate-deficient transferrin (CDT) are two markers of alcohol abuse. In the present study, we have compared " Hex B" with CDT as markers of alcohol abuse in a group of alcoholics hospitalized for detoxification after a period of heavy alcohol abuse. We have also followed the disappearance rate of these two markers from circulation. " Hex B" was elevated in 38 of 42 patients hospitalized for detoxication, whereas CDT was elevated in 35 of 42 patients. A highly significant correlation was noted between " Hex B" and CDT in these patients (p = 0.52, p < 0.001). Neither " Hex B" nor CDT correlated with gamma-glutamyltransferase or AST. The disappearance rates from serum of " Hex B" and CDT were determined in 21 hospitalized patients followed for up to 15 days. " Hex B" and CDT showed similar time-course variation and half-lives, 6.5 +/- 3.7 (mean +/- SD) and 8.6 +/- 4.1 days, respectively. The possible reasons for a relation between these two markers are discussed, and it is concluded that more experience of both " Hex B" and CDT in unselected populations is needed to establish the diagnostic potential of these tests as markers of alcohol abuse.
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Authors | B Hultberg, A Isaksson, M Berglund, C Alling |
Journal | Alcoholism, clinical and experimental research
(Alcohol Clin Exp Res)
Vol. 19
Issue 2
Pg. 452-6
(Apr 1995)
ISSN: 0145-6008 [Print] England |
PMID | 7625581
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Isoenzymes
- Transferrin
- carbohydrate-deficient transferrin
- Hexosaminidase B
- beta-N-Acetylhexosaminidases
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Topics |
- Adult
- Alcoholism
(diagnosis, enzymology, rehabilitation)
- Biomarkers
(blood)
- Female
- Half-Life
- Hexosaminidase B
- Humans
- Isoenzymes
(blood)
- Liver Function Tests
- Male
- Middle Aged
- Reference Values
- Transferrin
(analogs & derivatives, metabolism)
- beta-N-Acetylhexosaminidases
(blood)
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