[Severe acquired protein S deficiency with thrombophlebitis after febrile infection in a 7-year-old girl].

Abstract

The importance of the anticoagulant properties of protein S is illustrated by the high incidence of thromboembolic events in individuals with protein S-deficiency. A 7 year old girl was hospitalized with purpura-like bruises and lesions on both thighs after she had suffered from febrile infection. A subsequently developing thrombosis of the left V. femoralis was treated successfully with urokinase. Haemostaseological investigations showed no signs of disseminated intravascular coagulation. However, isolated severe degradation or all protein S-components due to the presence of a circulating autoantibody to protein S was found. After several months the antibody was detectable not any more, activity and antigens of protein S were normal.

• Authors: G Lutze, K J Hartung, V Aumann, U Mittler, C Luley
• Journal: Klinische Padiatrie (Klin Padiatr) 1995 May-Jun Vol. 207 Issue 3 Pg. 113-6 ISSN: 0300-8630 [Print] Germany
• Vernacular Title: Schwerer erworbener Protein S-Mangel mit Beinvenenthrombose nach fieberhaftem Infekt bei einem 7jährigen Mdchen.
• PMID: 7623427 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Carrier Proteins
• Integrin alphaXbeta2
• Heparin
• Urokinase-Type Plasminogen Activator
• Phenprocoumon

Topics

• Bacterial Infections (blood, complications)
• Blood Coagulation Tests
• Carrier Proteins (blood)
• Child
• Female
• Follow-Up Studies
• Heparin (administration & dosage, adverse effects)
• Humans
• Integrin alphaXbeta2
• Phenprocoumon (administration & dosage)
• Protein S Deficiency (blood, drug therapy)
• Thrombolytic Therapy
• Thrombophlebitis (blood, drug therapy)
• Urokinase-Type Plasminogen Activator (administration & dosage, adverse effects)