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[Severe acquired protein S deficiency with thrombophlebitis after febrile infection in a 7-year-old girl].

Abstract
The importance of the anticoagulant properties of protein S is illustrated by the high incidence of thromboembolic events in individuals with protein S-deficiency. A 7 year old girl was hospitalized with purpura-like bruises and lesions on both thighs after she had suffered from febrile infection. A subsequently developing thrombosis of the left V. femoralis was treated successfully with urokinase. Haemostaseological investigations showed no signs of disseminated intravascular coagulation. However, isolated severe degradation or all protein S-components due to the presence of a circulating autoantibody to protein S was found. After several months the antibody was detectable not any more, activity and antigens of protein S were normal.
AuthorsG Lutze, K J Hartung, V Aumann, U Mittler, C Luley
JournalKlinische Pàˆdiatrie (Klin Padiatr) 1995 May-Jun Vol. 207 Issue 3 Pg. 113-6 ISSN: 0300-8630 [Print] GERMANY
Vernacular TitleSchwerer erworbener Protein S-Mangel mit Beinvenenthrombose nach fieberhaftem Infekt bei einem 7jährigen Mdchen.
PMID7623427 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Carrier Proteins
  • Integrin alphaXbeta2
  • Heparin
  • Urokinase-Type Plasminogen Activator
  • Phenprocoumon
Topics
  • Bacterial Infections (blood, complications)
  • Blood Coagulation Tests
  • Carrier Proteins (blood)
  • Child
  • Female
  • Follow-Up Studies
  • Heparin (administration & dosage, adverse effects)
  • Humans
  • Integrin alphaXbeta2
  • Phenprocoumon (administration & dosage)
  • Protein S Deficiency (blood, drug therapy)
  • Thrombolytic Therapy
  • Thrombophlebitis (blood, drug therapy)
  • Urokinase-Type Plasminogen Activator (administration & dosage, adverse effects)

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