Abstract |
We have examined the antiviral activity of a crude extract prepared from the culture medium of the fungus Metarhizium anisopliae. Eight active destruxins were identified which showed strong suppressive effect on the production of the hepatitis B surface antigen ( HBsAg) in human hepatoma Hep3B cells. One new compound, desmethyldestruxin B2 [1], was isolated from M. anisopliae. This structure was determined based on its nmr and mass spectral data.
|
Authors | H Chen, S F Yeh, G T Ong, S H Wu, C M Sun, C K Chou |
Journal | Journal of natural products
(J Nat Prod)
Vol. 58
Issue 4
Pg. 527-31
(Apr 1995)
ISSN: 0163-3864 [Print] United States |
PMID | 7623030
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Culture Media
- Hepatitis B Surface Antigens
- Peptides, Cyclic
- desmethyldestruxin B2
|
Topics |
- Animals
- Culture Media
- Hepatitis B Surface Antigens
(biosynthesis)
- Humans
- Liver Neoplasms, Experimental
(metabolism)
- Magnetic Resonance Spectroscopy
- Mass Spectrometry
- Mitosporic Fungi
(chemistry)
- Peptides, Cyclic
(chemistry, isolation & purification, pharmacology)
- Tumor Cells, Cultured
|