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The novel desmethyldestruxin B2, from Metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells.

Abstract
We have examined the antiviral activity of a crude extract prepared from the culture medium of the fungus Metarhizium anisopliae. Eight active destruxins were identified which showed strong suppressive effect on the production of the hepatitis B surface antigen (HBsAg) in human hepatoma Hep3B cells. One new compound, desmethyldestruxin B2 [1], was isolated from M. anisopliae. This structure was determined based on its nmr and mass spectral data.
AuthorsH Chen, S F Yeh, G T Ong, S H Wu, C M Sun, C K Chou
JournalJournal of natural products (J Nat Prod) Vol. 58 Issue 4 Pg. 527-31 (Apr 1995) ISSN: 0163-3864 [Print] United States
PMID7623030 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Culture Media
  • Hepatitis B Surface Antigens
  • Peptides, Cyclic
  • desmethyldestruxin B2
Topics
  • Animals
  • Culture Media
  • Hepatitis B Surface Antigens (biosynthesis)
  • Humans
  • Liver Neoplasms, Experimental (metabolism)
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mitosporic Fungi (chemistry)
  • Peptides, Cyclic (chemistry, isolation & purification, pharmacology)
  • Tumor Cells, Cultured

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