[Local therapy and adjuvant interferon therapy in genital papilloma virus infections].

Abstract

OBJECTIVE:

Is it possible to reduce the recurrence rates of HPV-positive genital tract lesions by systemic interferon alfa-2a in addition to local therapy?

METHODS:

Thirty-three of 63 patients with first manifestation of papillomavirus infection or monolocal manifestation were treated by local therapy. The other 30 patients with recurrent or multiorgan infections received 3 courses with 12 x 10(6) IU interferon alfa-2a subcutaneously.

RESULTS:

For the remaining 47 patients (16 were lost to follow-up) we found a significantly lower recurrence rate of 21% (5 of 24) in the group of interferon-treated patients compared to 52% (12 of 23) of patients treated without interferon.

CONCLUSIONS:

The systemic treatment of HPV-positive genital tract lesions with interferon alfa-2a in addition to CO2 laser surgery or cone biopsy seems to reduce the recurrence rates of HPV-positive lesions.

• Authors: J Backe, T Roos, H Kaesemann, J Martius, M Ott
• Journal: Gynakologisch-geburtshilfliche Rundschau (Gynakol Geburtshilfliche Rundsch) Vol. 35 Issue 2 Pg. 79-84 ( 1995) ISSN: 1018-8843 [Print] Switzerland
• Vernacular Title: Lokaltherapie und adjuvante Interferontherapie bei genitalen Papillomvirusinfektionen.
• PMID: 7620386 (Publication Type: Journal Article)

Chemical References

• Interferon alpha-2
• Interferon-alpha
• Recombinant Proteins

Topics

• Adolescent
• Adult
• Biopsy
• Cervix Uteri (pathology)
• Child
• Combined Modality Therapy
• Condylomata Acuminata (pathology, therapy)
• Female
• Genital Neoplasms, Female (pathology, therapy)
• Humans
• Injections, Subcutaneous
• Interferon alpha-2
• Interferon-alpha (administration & dosage, adverse effects)
• Laser Therapy
• Middle Aged
• Neoplasm Recurrence, Local (pathology, therapy)
• Neoplasm Staging
• Papillomaviridae (drug effects)
• Papillomavirus Infections (pathology, therapy)
• Recombinant Proteins
• Tumor Virus Infections (pathology, therapy)
• Uterine Cervical Neoplasms (pathology, therapy)
• Vaginal Neoplasms (pathology, therapy)
• Vulvar Neoplasms (pathology, therapy)
• Uterine Cervical Dysplasia (pathology, therapy)