Antimicrobial resistance of Streptococcus pneumoniae in Finland, 1987-1990.

Abstract

A nationwide survey of the prevalence of antimicrobial resistance among Streptococcus pneumoniae isolates from the middle ear fluid of children with acute otitis media (639 strains) and from throat-swab samples of healthy children (149 strains) was conducted in Finland during 1987-1990. The MICs of penicillin, cephalothin, cefaclor, erythromycin, trimethoprim, and co-trimoxazole were determined by the agar dilution method. Low-level resistance to penicillin (MIC, 0.1-1 microgram/mL) was found in 1.7% of the otitis-related and 1.3% of the healthy-carrier strains. No highly penicillin-resistant strains (MIC, > or = 2 micrograms/mL) were found. Six multiresistant strains were detected, three of them possibly belonging to a previously identified clone present in Finland since 1985. Eighty-five percent of the resistant otitis-related strains, including 9 of the 11 moderately penicillin-resistant strains (4 of which were multiresistant), belonged to the three most common serogroups (6, 19, and 23).

• Authors: A Nissinen, M Leinonen, P Huovinen, E Herva, M L Katila, S Kontiainen, O Liimatainen, S Oinonen, A K Takala, P H Mäkelä
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 20 Issue 5 Pg. 1275-80 (May 1995) ISSN: 1058-4838 [Print] United States
• PMID: 7620010 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Acute Disease
• Child, Preschool
• Drug Resistance, Microbial
• Finland
• Humans
• Infant
• Infant, Newborn
• Microbial Sensitivity Tests
• Otitis Media (drug therapy, microbiology)
• Serotyping
• Streptococcus pneumoniae (drug effects)
• Time Factors