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Zidovudine is beneficial in human immunodeficiency virus associated nephropathy.

Abstract
Human immunodeficiency virus associated nephropathy (Hivan) is a distinct renal disease described in patients infected with the human immunodeficiency virus (HIV). Hivan is characterized by a nephrotic syndrome, enlarged kidneys, a histologic finding of focal and segmental glomerulosclerosis, and a very rapid progression to end-stage renal disease (ESRD). No therapeutic intervention has been shown, in a prospective evaluation, to either alter the course of established Hivan or to influence the emergence of Hivan in HIV-infected patients. We conducted a prospective study on 23 consecutively selected patients seen between 1989 and 1992 who were infected with the HIV, 14 (61%) of whom had significant proteinuria (> or = 2+). Percutaneous kidney biopsy was performed in 5 (36%) of the 14 subjects who had significant proteinuria, and histologic examination of the kidney tissue revealed focal and segmental glomerulosclerosis in all 5 cases. Of the 14 subjects with proteinuria, 8 (57%) also had azotemia (serum creatinine level > or = 1.3 mg/dl). Nine (39%) of 23 subjects admitted intravenous drug use, while 9 (39%) of 23 subjects have had an opportunistic infection before enrollment in the study. The known duration of HIV infection before initiation of zidovudine therapy was 10.3 +/- (SD) 8 months. The mean CD4 count before zidovudine therapy was 195.9 +/- 117 (range 21-654) cells/mm3. The mean dose of zidovudine administered was 543 +/- 117 (range 400-800) mg daily for a period of 20.4 +/- 11 (range 6-38) months.(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsO Ifudu, T K Rao, C C Tan, H Fleischman, K Chirgwin, E A Friedman
JournalAmerican journal of nephrology (Am J Nephrol) Vol. 15 Issue 3 Pg. 217-21 ( 1995) ISSN: 0250-8095 [Print] Switzerland
PMID7618646 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Zidovudine
Topics
  • AIDS-Associated Nephropathy (drug therapy, epidemiology, immunology)
  • Adult
  • CD4 Lymphocyte Count
  • Case-Control Studies
  • Disease Progression
  • Female
  • Humans
  • Kidney Failure, Chronic (epidemiology, prevention & control)
  • Male
  • Prospective Studies
  • Zidovudine (therapeutic use)

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