HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Characterization of the hypothermic effect of the synthetic cannabinoid HU-210 in the rat. Relation to the adrenergic system and endogenous pyrogens.

Abstract
In the present study we have characterized the hypothermic effect of the psychoactive cannabinoid HU-210, by investigating its interaction with the endogenous pyrogens, IL-1 and PGE2. We also studied the involvement of the adrenergic system in mediation of this hypothermic effect. Injection of HU-210 directly into the preoptic area caused a dose dependent reduction of rectal temperature from 37 to 32.1 degrees C. Injection of the non-psychoactive analog, HU-211 which does not bind to brain cannabinoid receptor, did not affect body temperature. Injection of the adrenergic agonists, CGP-12177 and clonidine (beta, and alpha adrenergic agonists, respectively) abrogated the hypothermia induced by HU-210. Injection of the adrenergic antagonists, prazosin (alpha 1) and propranolol (beta) enhanced the hypothermic effect of HU-210. Intracerebral administration of IL-1 or PGE2 to rats pretreated with HU-210 caused a transient inhibition of the hypothermia. The ex vivo rate of basal or bacterial endotoxin-induced synthesis of PGE2 by different brain regions, including the preoptic area was not affected by HU-210 administration. These results suggest that the synthetic cannabinoid HU-210 acts in the preoptic area, probably via the brain cannabinoid receptor to induce hypothermia. The hypothermic effect can be antagonized by adrenergic agonists and enhanced by adrenergic antagonists. HU-210 does not interfere with the pyrogenic effect of IL-1 or PGE2.
AuthorsH Ovadia, A Wohlman, R Mechoulam, J Weidenfeld
JournalNeuropharmacology (Neuropharmacology) Vol. 34 Issue 2 Pg. 175-80 (Feb 1995) ISSN: 0028-3908 [Print] England
PMID7617143 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cannabinoids
  • Interleukin-1
  • Pyrogens
  • Dronabinol
  • Dinoprostone
  • Clonidine
  • HU 211
Topics
  • Animals
  • Cannabinoids (biosynthesis)
  • Clonidine (pharmacology)
  • Dinoprostone (pharmacology)
  • Dose-Response Relationship, Drug
  • Dronabinol (analogs & derivatives, pharmacology)
  • Humans
  • Hypothermia (metabolism)
  • Interleukin-1 (pharmacology)
  • Male
  • Pyrogens (metabolism)
  • Rats
  • Temperature
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: