[Effective out-patient treatment of gastric ulcer with proglumide: preliminary results (author's transl)].

Abstract

In a double-blind trial 16 persons with gastric ulcer and 35 with duodenal ulcer were treated as out-patients with 1200 mg proglumide daily or 1320 mg magnesium tricilicate daily (as an "active placebo") for four weeks. The ulcers were assessed by endoscopy before and after treatment. The gastric ulcers disappeared in 75% of patients receiving proglumide (six of eight subjects) but in only 25% of those on the placebo (two of eight). There was no significant effect of proglumide on duodenal ulcers (17 in the proglumide and 18 in the placebo groups). Proglumide failed to affect either basal or maximally stimulated acid secretion, nor was there any change in the serum gastrin level. There were no side effects during proglumide administration. This underlines its therapeutic value in the treatment of gastric ulcer, in comparison with cimetidine or carbenoxolone.

• Authors: S E Miederer, H Lindstaedt, K Kutz, H Wuttke
• Journal: Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 104 Issue 9 Pg. 313-5 (Mar 02 1979) ISSN: 0012-0472 [Print] Germany
• Vernacular Title: Wirksame ambulante Therapie des Ulcus ventriculi mit Proglumid. Vorläufige Mitteilung.
• PMID: 761539 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Gastrins
• Placebos
• Glutamine
• Proglumide

Topics

• Adult
• Aged
• Ambulatory Care
• Double-Blind Method
• Duodenal Ulcer (diagnosis, drug therapy)
• Female
• Gastric Acidity Determination
• Gastrins (blood)
• Gastroscopy
• Glutamine (analogs & derivatives)
• Humans
• Male
• Middle Aged
• Placebos
• Proglumide (therapeutic use)
• Stomach Ulcer (diagnosis, drug therapy)