Beta-1-selectivity is not essential to achieve therapeutic efficacy with beta-blockade therapy for idiopathic dilated cardiomyopathy.

Abstract

This study investigated the therapeutic efficacy of two different beta-blockers, metoprolol (beta 1-selective) and nipradilol (nonselective) for the treatment of idiopathic dilated cardiomyopathy (DCM). The New York Heart Association functional class improved in the metoprolol group (n = 9) and the nipradilol group (n = 9), but not in the control group who received conventional therapy (n = 8). The left ventricular ejection fraction increased in both the beta-blocker groups (p < 0.01, p < 0.05). Lymphocyte beta-adrenoceptors were upregulated in the nipradilol group (p < 0.01). Cardiac events were less common in both the beta-blocker groups than in the control group (both p < 0.05). Thus, nipradilol improved symptoms and cardiac function with a favorable effect on sympathoneuronal activity as well as metoprolol in patients with DCM. Therefore, beta 1-selectivity is not essential to achieve therapeutic efficacy with beta-blockade therapy for DCM.

• Authors: T Yoshikawa, S Handa, M Akaishi, H Mitamura, S Ogawa
• Journal: Cardiology (Cardiology) Vol. 86 Issue 3 Pg. 217-23 ( 1995) ISSN: 0008-6312 [Print] Switzerland
• PMID: 7614494 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic beta-Antagonists
• Propanolamines
• Receptors, Adrenergic, beta
• nipradilol
• Metoprolol

Topics

• Adrenergic beta-Antagonists (therapeutic use)
• Adult
• Aged
• Cardiomyopathy, Dilated (diagnostic imaging, drug therapy, metabolism)
• Confounding Factors, Epidemiologic
• Coronary Angiography
• Electrocardiography
• Female
• Humans
• Lymphocytes (drug effects, metabolism)
• Male
• Metoprolol (therapeutic use)
• Middle Aged
• Propanolamines (therapeutic use)
• Radionuclide Ventriculography
• Receptors, Adrenergic, beta (drug effects)
• Ventricular Function, Left (drug effects)