Intravesical antitumor therapy immediately after transurethral resection of bladder cancer.

Abstract

Patients with superficial transitional cell cancer of the urinary bladder were entered into a randomized trial to compare the effects of immediate and short-term postoperative instillation of peplomycin sulfate with simple irrigation. Although the recurrence-free rate of the 46 peplomycin-treated patients was lower, the difference was not significant. Repeated washing of the bladder at the end of transurethral resection might partly replace the role of cytotoxic therapy.

• Authors: K Fujita
• Journal: International journal of urology : official journal of the Japanese Urological Association (Int J Urol) Vol. 1 Issue 4 Pg. 341-4 (Dec 1994) ISSN: 0919-8172 [Print] Australia
• PMID: 7614398 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Peplomycin

Topics

• Administration, Intravesical
• Aged
• Carcinoma, Transitional Cell (drug therapy)
• Dose-Response Relationship, Drug
• Female
• Humans
• Male
• Middle Aged
• Neoplasm Staging
• Peplomycin (administration & dosage, blood)
• Recurrence
• Therapeutic Irrigation
• Time Factors
• Tumor Cells, Cultured (drug effects)
• Urinary Bladder Neoplasms (drug therapy, surgery)