[Inhibitory effects of menogaril to the proliferation of HTLV-I infected T-cell lines and fresh tumor cells from adult T-cell leukemia patients].

Abstract

Anti-cancer effect of anthracyclines are well established. In vitro inhibitory effects of a new anthracyclin-derivative drug, menogaril (TUT-7) which is developed for oral administration, on three human T-cell leukemia virus type-I (HTLV-I) infected T-cell lines, a HTLV-I non-infected T cell line, and fresh tumor cells from four adult T-cell leukemia (ATL) cases are evaluated and compared to those of doxorubicin. The inhibitory effects of TUT-7 is almost as much as those of doxorubicin. Both TUT-7 and doxorubicin induced apoptosis to a HTLV-I infected cell line and inhibited proliferation of fresh tumor cells from ATL of chronic, acute and lymphoma type in a dose dependent manner. We have already reported that skin eruption of ATL patient improved by oral administration of TUT-7. This new anthracyclin-derivative would be useful in treating ATL patients even in out-patients clinic keeping a good quality of life.

• Authors: H Hata, H Matsuzaki, N Kuribayashi, S Takemoto, M Matsuoka, K Takatsuki
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 22 Issue 8 Pg. 1057-61 (Jul 1995) ISSN: 0385-0684 [Print] Japan
• PMID: 7611758 (Publication Type: English Abstract, Journal Article)

Chemical References

• Doxorubicin
• Menogaril

Topics

• Apoptosis (drug effects)
• Cell Line
• Doxorubicin (pharmacology)
• Female
• HTLV-I Infections (pathology)
• Humans
• Leukemia-Lymphoma, Adult T-Cell (pathology)
• Male
• Menogaril (pharmacology)
• T-Lymphocytes (drug effects, virology)
• Tumor Cells, Cultured