Abstract | AIM OF THE STUDY: The aim of this study is to test the effect of low dose radiation on the subfoveal neovascular membranes (SNVM) and to analyse visual acuity in age-related macular degeneration. METHODS AND PATIENTS: From November 1993 through to August 1994, 10 patients, on the one hand, were given a dose of 5 Gy followed by controls 6 weeks and 6 months later. On the other hand, 21 patients were treated with a dose of 8 Gy and were subjected to controls 6 weeks later. Before the radiotherapy and during the control sessions, all patients were required to be measured for different parameters of visual acuity and to receive a simultaneous fluorescein and indocyanine green angiography. The radiotherapy was done by a linear accelerator 6 MeV and through a lateral port 3 x 4 cm in half beam technic. RESULTS: In the 5 Gy group, no changes in the parameters for visual acuity were noted in most cases after 6 months. In 9 of the cases, the membranes had increased in size and in 1 case, they had remained unchanged. In the 8 Gy group, no changes in the visual acuity or in the membrane size were diagnosed. Of all the patients treated, only one refused the angiography control. DISCUSSION AND CONCLUSIONS: Given the low dose used and the period of observation, the visual acuity of all patients remained stable. The size of the membranes increased in most cases for those 5 Gy patients and in this respect, no changes at all were noted in the 8 Gy patients. In order to better evaluate the potential of radiotherapy, this study must be pursued and coupled with further studies analysing the effect of different doses on patients.
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Authors | C Valmaggia, P Bischoff, G Ries |
Journal | Klinische Monatsblatter fur Augenheilkunde
(Klin Monbl Augenheilkd)
Vol. 206
Issue 5
Pg. 343-6
(May 1995)
ISSN: 0023-2165 [Print] Germany |
Vernacular Title | Niedrig dosierte Radiotherapie der subfoveolären Neovaskularisationen bei altersabhängiger Makuladegeneration. Vorläufige Resultate. |
PMID | 7609382
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Topics |
- Aged
- Female
- Fluorescein Angiography
- Follow-Up Studies
- Humans
- Macular Degeneration
(diagnosis, radiotherapy)
- Male
- Radiotherapy Dosage
- Retinal Neovascularization
(diagnosis, radiotherapy)
- Visual Acuity
(radiation effects)
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