[Clinical results of IV-compa (cisplatin, vincristine, methotrexate, peplomycin and adriamycin) chemotherapy for advanced urothelial cancer].

Abstract

We have developed a new combination intravenous chemotherapy regimen called COMPA (IV-COMPA). The clinical value of IV-COMPA chemotherapy was evaluated based on the results of 24 patients with urothelial cancers. From October 1989 through October 1993, a total of 24 patients (20 males and 4 females) received IV-COMPA chemotherapy at Tokyo Medical College Hospital and Tokyo Medical College Hachioji Medical Center. All patients had advanced transitional cell carcinoma or adenocarcinoma of the urothelial tract (renal pelvis, ureter or bladder). One course of IV-COMPA was delivered at 2-week intervals and consisted of 30 mg/m2 CDDP on day 4 and 5, 0.6 mg/m2 VCR (Oncovin) on day 1 and 2, 5 mg/m2 MTX on day 2 and 3, 5 mg/m2 PEP on day 1, 2 and 3, 20 mg/m2 ADM on day 4. A few patients received the same regimen without peplomycin called IV-COMA to avoid pulmonary fibrosis. Fifteen patients with surgically confirmed invasive carcinoma were defined by at least 1 of the following criteria: multiple tumors or size greater than 5 cm, grade 3, stage P3 or P4, pN+, pR1, pL1, pV1, or secondary carcinoma in situ. These patients were treated with 2 or 3 corpses of postoperative IV-COMPA chemotherapy to improve prognosis. In this group, 14 of 15 (93%) are alive at a median follow-up of 22 months (range, 8-57 months) and actuarial survival rates of 1 and 3 years were 100%, 90.9%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: S Tsujino, Y Ono, S Yamamoto, M Tsuzuki, M Miki, T Aizawa, T Matsumoto, T Yamauchi
• Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology (Nihon Hinyokika Gakkai Zasshi) Vol. 86 Issue 6 Pg. 1164-71 (Jun 1995) ISSN: 0021-5287 [Print] Japan
• PMID: 7609360 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Peplomycin
• Vincristine
• Doxorubicin
• Cisplatin
• Methotrexate

Topics

• Adenocarcinoma (drug therapy)
• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Transitional Cell (drug therapy)
• Cisplatin (therapeutic use)
• Doxorubicin (therapeutic use)
• Drug Administration Schedule
• Female
• Humans
• Infusions, Intravenous
• Injections, Intramuscular
• Kidney Neoplasms (drug therapy)
• Kidney Pelvis
• Male
• Methotrexate (therapeutic use)
• Middle Aged
• Peplomycin (therapeutic use)
• Urinary Bladder Neoplasms (drug therapy)
• Vincristine (therapeutic use)