Abstract | OBJECTIVES: BACKGROUND: Efforts continue to identify a thrombolytic regimen that induces rapid, complete and sustained coronary artery patency in acute myocardial infarction. The two endogenous plasminogen activators rt-PA and pro-urokinase have been shown experimentally to induce fibrinolysis by sequential and complementary mechanisms. As a result, certain combinations of these activators have been found to be synergistic in vitro and in vivo. METHODS: In a multicenter observational study with core facilities for angiographic and laboratory analysis, 101 patients with acute myocardial infarction were enrolled and given a low dose bolus of rt-PA (5 to 10 mg) followed by a 90-min infusion of pro-urokinase (40 mg/h). All patients received intravenous heparin and oral aspirin. Coronary angiography was performed in all patients at 90 min. RESULTS: Angiography at 90 min showed the infarct-related artery to be patent (Thrombolysis in Myocardial Infarction [TIMI] grade 2 or 3 flow) in 77% of patients, and 60% achieved TIMI grade 3 flow. At one center, angiography was repeated at 24 h to detect a possible reocclusion. All 28 patients with a patent infarct-related artery at 90 min had patency at 24 h (82% achieved TIMI grade 3 flow). Treatment was well tolerated, with bleeding complications essentially confined to arterial puncture site hematomas. There was only one in-hospital death. CONCLUSIONS: A sequential combination of low dose rt-PA and reduced-dose pro-urokinase produced a high TIMI 3 patency rate, was well tolerated and was associated with a low reocclusion rate.
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Authors | S W Zarich, G J Kowalchuk, W D Weaver, J Loscalzo, M Sassower, K Manzo, C Byrnes, J E Muller, V Gurewich |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 26
Issue 2
Pg. 374-9
(Aug 1995)
ISSN: 0735-1097 [Print] United States |
PMID | 7608437
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Enzyme Precursors
- Fibrinolytic Agents
- Recombinant Proteins
- Tissue Plasminogen Activator
- Urokinase-Type Plasminogen Activator
- saruplase
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Topics |
- Adult
- Aged
- Confounding Factors, Epidemiologic
- Coronary Angiography
- Enzyme Precursors
(therapeutic use)
- Female
- Fibrinolytic Agents
(therapeutic use)
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(diagnostic imaging, drug therapy)
- Recombinant Proteins
(therapeutic use)
- Thrombolytic Therapy
(adverse effects, methods)
- Time Factors
- Tissue Plasminogen Activator
(therapeutic use)
- Treatment Outcome
- Urokinase-Type Plasminogen Activator
(therapeutic use)
- Vascular Patency
(drug effects)
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