Antiviral activity of an immunomodulatory lipophilic desmuramyl dipeptide analog.

Abstract

BCH-527, the lipophilic hydrochloride salt of octadecyl D-alanyl L-glutamine, was evaluated for efficacy against experimentally induced murine cytomegalovirus (MCMV), influenza A (H1N1) (IV-A), and Punta Toro virus (PTV) infections in mice. The compound was administered i.p. every other day for a total of 4 injections commencing 24 h previrus exposure. Doses ranged from 12.5 to 200 mg/kg per injection in the various experiments. The MCMV infection was significantly inhibited in two experiments by doses of 25-200 mg/kg, as manifested by increased numbers of survivors and decreased titers of virus recoverable from tissues. The IV-A infection was weakly inhibited, with antiviral activity seen in lowered lung scores and lung weights and less decline in arterial oxygen saturation values. The PTV infection was not inhibited. BCH-527 was stimulatory to cytotoxic T-cells, natural killer (NK) cells, macrophages, and splenic B-cells. The highest dose tested, 200 mg/kg, was inhibitory to cytotoxic T-cell activity and to some extent to NK cell and macrophage activity. These data suggest BCH-527 functions as an immune modulator in exerting the observed antiviral activity.

• Authors: R W Sidwell, D F Smee, J H Huffman, K W Bailey, R P Warren, R A Burger, C L Penney
• Journal: Antiviral research (Antiviral Res) Vol. 26 Issue 2 Pg. 145-59 (Mar 1995) ISSN: 0166-3542 [Print] Netherlands
• PMID: 7605113 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Adjuvants, Immunologic
• Antiviral Agents
• Dipeptides
• octadecyl alanylglutamate hydrochloride

Topics

• Adjuvants, Immunologic (pharmacology)
• Animals
• Antiviral Agents (pharmacology)
• Dipeptides (pharmacology)
• Female
• Herpesviridae Infections (drug therapy, immunology)
• Influenza A virus
• Killer Cells, Natural (drug effects, immunology)
• Macrophages (drug effects, immunology)
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Molecular Structure
• Muromegalovirus
• Orthomyxoviridae Infections (drug therapy, immunology)
• T-Lymphocytes, Cytotoxic (drug effects, immunology)