[The immunological criteria in the expediency of prescribing T-activin to patients with primary pulmonary tuberculosis].

Abstract

The paper presents results of the in vitro study of the immunomodulating effect of T-activin in 54 patients with active primary pulmonary tuberculosis, with the purpose of establishing criteria for initiating the therapy with this preparation. The most sensitive test for the determination of immunomodulating effect of T-activin in vitro appeared to be the reaction of active rosette forming (Ea-RFCs). The investigations performed showed that the preparation of the thymus gland can be recommended for use in those patients only, in whom there is striking or moderate decrease in the count of active RFCs. In the presence of their normal content T-activin may bring about depression of cellular immunity.

• Authors: M I Sakhelashvili-Haladzhun
• Journal: Likars'ka sprava (Lik Sprava) 1994 Sep-Dec Issue 9-12 Pg. 103-5 ISSN: 1019-5297 [Print] Ukraine
• Vernacular Title: Imunolohichni kryteriï dotsil'nosti pryznachennia T-aktyvinu khvorym na pervynnyĭ tuberkul'oz lehen'.
• PMID: 7604543 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Antitubercular Agents
• Peptides
• Thymus Extracts
• T-activin

Topics

• Adjuvants, Immunologic (therapeutic use)
• Adolescent
• Adult
• Antitubercular Agents (therapeutic use)
• B-Lymphocytes (drug effects, immunology)
• Drug Therapy, Combination
• Humans
• Peptides (therapeutic use)
• Rosette Formation
• T-Lymphocytes (drug effects, immunology)
• Thymus Extracts (therapeutic use)
• Tuberculosis, Pulmonary (drug therapy, immunology)