Abstract |
Somatostatin has been demonstrated to activate phosphotyrosine phosphatases (PTPases) in pancreatic cells. In this work we studied the effect of a tumor-selective somatostatin structural derivative, TT2-32, on the PTPase activity in the SW620 human colon tumor cell line. TT2-32 caused a strong inhibition of cell proliferation. In response to TT2-32 we found a rapid and sustained increase (5-30 min) in PTPase activity showing two maxima at 0.1 and 30 microM concentrations, respectively. During short-term incubation tyrosine kinase activity was much less affected by TT2-32. TT2-32-induced activation of PTPases may be an important early step in the signaling cascade in the inhibition of cell proliferation in colon carcinomas.
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Authors | T Vántus, P Csermely, I Teplán, G Kéri |
Journal | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
(Tumour Biol)
Vol. 16
Issue 4
Pg. 261-7
( 1995)
ISSN: 1010-4283 [Print] Netherlands |
PMID | 7604207
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- TT2-32
- Somatostatin
- Protein-Tyrosine Kinases
- Protein Tyrosine Phosphatases
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Topics |
- Amino Acid Sequence
- Antineoplastic Agents
(pharmacology)
- Cell Division
(drug effects)
- Colonic Neoplasms
(drug therapy, enzymology, pathology)
- Enzyme Activation
(drug effects)
- Humans
- Molecular Sequence Data
- Protein Tyrosine Phosphatases
(drug effects, metabolism)
- Protein-Tyrosine Kinases
(drug effects, metabolism)
- Signal Transduction
(drug effects, physiology)
- Somatostatin
(analogs & derivatives, pharmacology)
- Tumor Cells, Cultured
(drug effects, enzymology)
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