Effects of cyclosporine A on experimental hepatic metastases of mouse colon-26 tumour.

Abstract

Cyclosporine A (CSA), an immunosuppressive agent with apparently selective effects on T lymphocytes and little myelotoxicity, was tested for its effects on hepatic metastases by inoculation of mouse colon-26 tumour cells into the portal vein in male CDF1 mice. CSA, given subcutaneously in daily doses of 10-50 mg/kg/day, for 22 days, significantly increased the incidence of hepatic nodules. This increase was positively correlated with the CSA dose. When 5-fluorouracil was injected at a dose of 15 mg/kg/day every other day after the inoculation of tumour cells a highly significant reduction in the incidence of metastases was seen (compared with the controls). This strong inhibitory effect of 5-fluorouracil on metastasis was almost completely suppressed when mice were treated with CSA concomitantly. The results suggest that CSA affects the host immune system, accelerating the production of hepatic metastases.

• Authors: N Suzaki, S Fuchimoto, H Iwagaki, K Orita
• Journal: The Journal of international medical research (J Int Med Res) 1995 Mar-Apr Vol. 23 Issue 2 Pg. 112-8 ISSN: 0300-0605 [Print] England
• PMID: 7601293 (Publication Type: Journal Article)

Chemical References

• Cyclosporine
• Fluorouracil

Topics

• Adenocarcinoma (pathology, secondary)
• Animals
• Antibody Formation (drug effects)
• Cell Division (drug effects)
• Colonic Neoplasms (pathology)
• Cyclosporine (antagonists & inhibitors, therapeutic use)
• Fluorouracil (pharmacology)
• Injections, Intravenous
• Liver Neoplasms, Experimental (drug therapy, secondary)
• Male
• Mice
• Neoplasm Transplantation
• Portal Vein
• T-Lymphocytes (drug effects)
• Tumor Cells, Cultured