| Abstract | Cyclosporine A (CSA), an immunosuppressive agent with apparently selective effects on T lymphocytes and little myelotoxicity, was tested for its effects on hepatic metastases by inoculation of mouse colon-26 tumour cells into the portal vein in male CDF1 mice. CSA, given subcutaneously in daily doses of 10-50 mg/kg/day, for 22 days, significantly increased the incidence of hepatic nodules. This increase was positively correlated with the CSA dose. When 5-fluorouracil was injected at a dose of 15 mg/kg/day every other day after the inoculation of tumour cells a highly significant reduction in the incidence of metastases was seen (compared with the controls). This strong inhibitory effect of 5-fluorouracil on metastasis was almost completely suppressed when mice were treated with CSA concomitantly. The results suggest that CSA affects the host immune system, accelerating the production of hepatic metastases. |
| Authors | N Suzaki, S Fuchimoto, H Iwagaki, K Orita
(Affiliation: First Department of Surgery, Okayama University Medical School, Japan.)
|
| Journal | The Journal of international medical research
(J Int Med Res)
1995 Mar-Apr
Vol. 23
Issue 2
Pg. 112-8
ISSN: 0300-0605 ENGLAND |
| PMID | 7601293
(Publication Type: Journal Article)
|
| Chemical References |
- Fluorouracil
- Cyclosporine
|
| Topics |
- Adenocarcinoma
(pathology, secondary)
- Animals
- Antibody Formation
(drug effects)
- Cell Division
(drug effects)
- Colonic Neoplasms
(pathology)
- Cyclosporine
(antagonists & inhibitors, therapeutic use)
- Fluorouracil
(pharmacology)
- Injections, Intravenous
- Liver Neoplasms, Experimental
(drug therapy, secondary)
- Male
- Mice
- Neoplasm Transplantation
- Portal Vein
- T-Lymphocytes
(drug effects)
- Tumor Cells, Cultured
|
