Non-synergistic relaxant effects of vasoactive intestinal polypeptide and SIN-1 in human isolated cavernous artery and corpus cavernosum.

Abstract

Since vasoactive intestinal peptide (VIP) and nitric oxide (NO) are considered to be non-adrenergic, non-cholinergic (NANC) inhibitory mediators in human penile erectile tissue, the goal of this study was to discover possible synergistic effects of exogeneous VIP and the NO donor 3-morpholino-sydnonimine (SIN-1) in human isolated cavernous arteries and cavernosal smooth muscle. In contrast to VIP, SIN-1 elicited complete and reproducible relaxant actions. Combined administration of VIP and SIN-1 revealed non-synergistic, independent relaxant effects in both investigated tissues. The results do not favour a combined administration of VIP and SIN-1 as a new therapeutic approach in the treatment of erectile dysfunction.

• Authors: R G Hempelmann, I Papadopoulos, S Herzig
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 276 Issue 3 Pg. 277-80 (Apr 04 1995) ISSN: 0014-2999 [Print] Netherlands
• PMID: 7601214 (Publication Type: Journal Article)

Chemical References

• Vasodilator Agents
• Phenylephrine
• Vasoactive Intestinal Peptide
• linsidomine
• Molsidomine

Topics

• Arteries (drug effects)
• Drug Interactions
• Humans
• In Vitro Techniques
• Isometric Contraction (drug effects)
• Male
• Molsidomine (analogs & derivatives, pharmacology)
• Muscle Relaxation (drug effects)
• Muscle, Smooth (drug effects)
• Muscle, Smooth, Vascular (drug effects)
• Penis (blood supply, drug effects)
• Phenylephrine (pharmacology)
• Regional Blood Flow (drug effects)
• Vasoactive Intestinal Peptide (pharmacology)
• Vasodilator Agents (pharmacology)