Histidine ameliorated brain edema and cardiac dysfunction during local thrombotic cerebral ischemia in rats.

Abstract

AIM:

To observe the effects of histidine (i.v. 5 mg.kg-1) on brain edema and cardiac disturbance after cerebral thrombosis.

METHODS:

Regional cerebral thrombosis was induced by photochemical method in rats.

RESULTS:

It was showed that the brain water content increased markedly (85.6 +/- 3.8%, P < 0.01); the left ventricular systolic pressure (LVSP, 17.9 +/- 1.5 kPa) and the maximal left ventricular contractility decreased (+dp/dtmax 645 +/- 110 kPa and -dp/dtmax 473 +/- 106 kPa, P < 0.05). In rats treated with histidine after photochemical reaction, the brain water content decreased (81.5 +/- 2.0%) while LVSP (21.2 +/- 1.1 kPa) and left ventricular +dp/dtmax and -dp/dtmax increased markedly (777 +/- 144 kPa and 604 +/- 157 kPa, respectively).

CONCLUSION:

Histidine has protective effects on the brain and cardiac function during cerebral thrombosis.

• Authors: S Q Li, H Han, J He
• Journal: Zhongguo yao li xue bao = Acta pharmacologica Sinica (Zhongguo Yao Li Xue Bao) Vol. 16 Issue 2 Pg. 156-9 (Mar 1995) ISSN: 0253-9756 [Print] China
• PMID: 7597919 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Histidine

Topics

• Animals
• Brain Edema (drug therapy, etiology)
• Histidine (therapeutic use)
• Intracranial Embolism and Thrombosis (complications)
• Male
• Myocardial Contraction (drug effects)
• Rats
• Rats, Wistar
• Ventricular Function, Left (drug effects)