Endosonographic evaluation of the quality of ulcer healing induced by proton pump inhibitors.

We studied 26 gastric ulcer patients who were treated with a proton pump inhibitor to evaluate the quality of ulcer healing using endoscopic ultrasonography (EUS), and we examined the relationship between ulcer recurrence and contraction demonstrated on ulcer echoes (study I). The effect of lansoprazole versus an H2-receptor antagonist on the contraction of ulcer echoes (study II) was also investigated. In study I, gastric ulcer patients who demonstrated early healing by endoscopy often had shallow Ul-II or Ul-III ulcers and small cross-sectional areas on ulcer echoes. The early contraction on ulcer echo was associated with lower rates of ulcer relapse, and might therefore be indicative of a good quality of healing. In study II, the ulcer contraction rate after 8 weeks of treatment with lansoprazole was 71.8%, significantly higher than that achieved with H2-receptor antagonists. However, the mean cross-sectional area of gastric ulcer after 8 weeks of treatment with lansoprazole was 113.9 mm2. In conclusion, although lansoprazole was suitable for initial therapy in peptic ulcer patients, the quality of ulcer healing based on EUS findings did not appear to be adequate in patients treated for the short periods of time in this study.
AuthorsY Tsukamoto, H Goto, S Hase, Y Niwa, T Arisawa, T Hayakawa, H Yoshikane
JournalJournal of clinical gastroenterology (J Clin Gastroenterol) Vol. 20 Suppl 2 Pg. S40-3 ( 1995) ISSN: 0192-0790 [Print] UNITED STATES
PMID7594337 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Anti-Ulcer Agents
  • Histamine H2 Antagonists
  • Proton Pump Inhibitors
  • Lansoprazole
  • Omeprazole
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Anti-Ulcer Agents (therapeutic use)
  • Gastric Mucosa (pathology)
  • Gastroscopy
  • Histamine H2 Antagonists (therapeutic use)
  • Humans
  • Lansoprazole
  • Omeprazole (analogs & derivatives, therapeutic use)
  • Proton Pump Inhibitors
  • Stomach Ulcer (drug therapy, pathology, ultrasonography)

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