Abstract | BACKGROUND: METHOD: Eleven patients who met DSM-III-R criteria for borderline personality disorder were entered into an 8-week study of valproate. Exclusion criteria included current major depression or major medical disorder. All patients were in psychotherapy at least once a week for a minimum of 8 weeks prior to starting medication. Valproate was increased as tolerated to reach blood levels of 50 to 100 micrograms/mL. Clinician- and self-rated scales were completed each week. RESULTS: Three patients did not complete the study. Of completers, 4 of 8 patients were responders ("much less" or "less") on clinician-rated change scores for overall pathology and for mood. Three of 8 patients were responders on change scores for anxiety, anger, impulsivity, and rejection sensitivity. There was a significant (p = .03) decrease in total Symptom Checklist-90 scores between the start and end of the trial. On the Overt Aggression Scale (Modified), total other-directed assault did not significantly decrease, but there was a significant (p = .02) decrease in global subjective irritability. CONCLUSION:
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Authors | D J Stein, D Simeon, M Frenkel, M N Islam, E Hollander |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 56
Issue 11
Pg. 506-10
(Nov 1995)
ISSN: 0160-6689 [Print] United States |
PMID | 7592502
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Ambulatory Care
- Borderline Personality Disorder
(diagnosis, drug therapy, psychology)
- Drug Administration Schedule
- Female
- Humans
- Male
- Personality Inventory
- Psychiatric Status Rating Scales
- Treatment Outcome
- Valproic Acid
(administration & dosage, therapeutic use)
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