Decreased biotolerability for ivermectin and cyclosporin A in mice exposed to potent P-glycoprotein inhibitors.

Abstract

SDZ PSC 833 or SDZ 280-446 are strong blockers of the function of class I mdr gene-encoded P-glycoprotein molecules, which were developed for the reversal of multi-drug-resistance of tumor cells. When treated with such drugs, normal mice may display hypersensitivity to cyclosporin A and ivermectin. The recorded signs of acute toxicity are compatible with alterations of the murine central nervous system functions and with earlier data suggesting that P-glycoprotein expressed at the murine blood-brain barrier might be involved in the exclusion of cyclosporin A or ivermectin from brain tissue.

• Authors: A D Didier, F Loor
• Journal: International journal of cancer (Int J Cancer) Vol. 63 Issue 2 Pg. 263-7 (Oct 09 1995) ISSN: 0020-7136 [Print] United States
• PMID: 7591215 (Publication Type: Journal Article)

Chemical References

• ATP Binding Cassette Transporter, Subfamily B, Member 1
• Cyclosporins
• Peptides, Cyclic
• SDZ 280 446
• Ivermectin
• Cyclosporine
• valspodar

Topics

• ATP Binding Cassette Transporter, Subfamily B, Member 1 (antagonists & inhibitors)
• Animals
• Blood-Brain Barrier
• Cyclosporine (administration & dosage)
• Cyclosporins (pharmacology)
• Drug Resistance, Multiple
• Drug Tolerance
• Hybridization, Genetic
• Ivermectin (administration & dosage)
• Mice
• Mice, Inbred C57BL
• Mice, Inbred DBA
• Peptides, Cyclic (pharmacology)