Azithromycin levels in cervical mucus and plasma after a single 1.0g oral dose for chlamydial cervicitis.

Abstract

OBJECTIVE:

To determine the kinetics of azithromycin in cervical mucus and plasma.

SUBJECTS AND METHODS:

Azithromycin concentrations were determined in plasma and mucus samples from 20 women with cervical chlamydial infection one, seven and fourteen days after a single oral 1.0 g dose.

RESULTS:

In mucus, all measurable azithromycin concentrations were above the minimal inhibitory concentration against Chlamydia trachomatis on day 7 as well as on day 14.

CONCLUSION:

The high cervical mucus concentrations of azithromycin can explain the high clinical and microbiological efficacy.

• Authors: A M Worm, A Osterlind
• Journal: Genitourinary medicine (Genitourin Med) Vol. 71 Issue 4 Pg. 244-6 (Aug 1995) ISSN: 0266-4348 [Print] England
• PMID: 7590717 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Azithromycin

Topics

• Administration, Oral
• Anti-Bacterial Agents (administration & dosage, pharmacokinetics)
• Azithromycin (administration & dosage, pharmacokinetics)
• Cervix Mucus (metabolism)
• Female
• Humans
• Treatment Outcome
• Uterine Cervicitis (drug therapy, metabolism)