[Clinical experience using the cryoprotector "hecmolit" in performing autologous bone marrow transplantation].

Abstract

The authors summarize clinical evidence obtained on the efficacy of a new Russian cryoprotector hecmolit in the conduction of autotransplantation of 8 patients with acute leukemia. The markers of the preserved hemopoietic potential of the unfrozen bone marrow were the amount of myelokaryocytes, their viability in the test with vital stain, CFU-GM level. Infusions of the marrow suspension incorporating hecmolit (120-180 ml) produced minimaL side effects. After thawing myelokaryocytes remained in the amount 81.7 +/- 8.2% or 1.6 +/- 0.4 x 10(8) cell / kg, on the average. Estimation of the aggregates in terms of the weight revealed that hemopoietic potential was sufficient for the transplant survival (2.9 +/- 0.7 x 10(3) CFU-GM/kg) though only 50 +/- 10% of CFU-GM remained safe. Hecmolit tolerance was satisfactory. The preparation is thought convenient for bone marrow transplantation practice.

• Authors: K M Abdulkadyrov, S I Moiseev, A A Ganapiev, S V Gritsaev, V A Balashova, A E Golubev
• Journal: Gematologiia i transfuziologiia (Gematol Transfuziol) 1995 Mar-Apr Vol. 40 Issue 2 Pg. 40-2 ISSN: 0234-5730 [Print] Russia (Federation)
• Vernacular Title: Opyt klinicheskogo primeneniia krioprotektora "gekmolit" pri provedenii autologichnoĭ transplantatsii kostnogo mozga.
• PMID: 7590067 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cryoprotective Agents
• Organic Chemicals
• hecmolit

Topics

• Adolescent
• Adult
• Bone Marrow Transplantation
• Cryoprotective Agents (therapeutic use)
• Humans
• Organic Chemicals
• Transplantation, Autologous