[Peliosis hepatitis during intestinal lymphomatous polyposis treated with chemotherapy and radiotherapy. Regression after antibiotic therapy].

Abstract

We report a case of regressive peliosis hepatis, which occurred in a 55 year-old woman with diffuse intestinal lymphomatous polyposis in remission after treatment with chemotherapy and radiotherapy, and which was cleared after one month treatment with erythromycin. The Warthin-Sarry stain, performed to identify a specific agent such as Rochalimaea quintana and henselae, was negative, and the polymerase chain reaction technique could not be performed. Regressive cases of peliosis hepatis are rare, and 4 out of 7 have been reported after antibiotic treatment. Two of them were observed after an antibiotic regimen with erythromycin in patients with HIV disease, and the bacilli Rochalimaea quintana and henselae were identified in liver tissue with Warthin-Starry stain and polymerase chain reaction technique. The observation and the regressive cases recently reported elsewhere, suggest that appropriate antibiotic treatment should be proposed when peliosis hepatis occurs.

• Authors: N Abdelli, Y Bouhnik, A Lavergne-Slove, B Messing, A Galian, J C Rambaud
• Journal: Gastroenterologie clinique et biologique (Gastroenterol Clin Biol) Vol. 19 Issue 5 Pg. 537-41 (May 1995) ISSN: 0399-8320 [Print] France
• Vernacular Title: Péliose hépatique au cours d'une polypose lymphomateuse intestinale traitée par chimiothérapie et radiothérapie. Régression après antibiothérapie.
• PMID: 7590008 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Erythromycin

Topics

• Anti-Bacterial Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Combined Modality Therapy
• Erythromycin (therapeutic use)
• Female
• Humans
• Intestinal Neoplasms (complications, drug therapy, radiotherapy)
• Lymphoma, Non-Hodgkin (complications, drug therapy, radiotherapy)
• Middle Aged
• Peliosis Hepatis (drug therapy, etiology, pathology)
• Remission Induction