HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

DNA photocleavage by novel intercalating 6-(2-pyridinium)phenanthridinium viologens.

Abstract
A new type of DNA-intercalating viologen dications, derived from the N,N'-dialkyl-6-(2-pyridyl)phenanthridine structure (in which dialkyl is -CH2CH2-,-CH2CH2CH2-, or (-CH3)2, abbreviated dq2pyp, dq3pyp, and Me2pyp, respectively), are able to produce frank strand breaks in supercoiled plasmid DNA upon irradiation with visible light. The amount of photocleavage is similar for the three drugs. The observed DNA photosensitization appears to follow a single-strand cleavage model, as shown by a kinetic analysis of the reaction with dq2pyp. The photodynamic action of the drugs seems to be initiated by a light-induced electron transfer reaction from the nucleobases, given the singlet excited-state redox potentials (ca. + 2.1 V vs. SHE) and the low quantum yields of singlet molecular oxygen production of the drugs (0.1-0.2 in aerated D2O).
AuthorsG Colmenarejo, M Bárcena, M C Gutiérrez-Alonso, F Montero, G Orellana
JournalFEBS letters (FEBS Lett) Vol. 374 Issue 3 Pg. 426-8 (Nov 06 1995) ISSN: 0014-5793 [Print] England
PMID7589585 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA, Superhelical
  • Intercalating Agents
  • N,N'-dimethyl-6-(2-pyridinium)phenanthridinium
  • N,N'-ethylene-6-(2-pyridinium)phenanthridinium
  • N,N'-propylene-6-(2-pyridinium)phenanthridinium
  • Phenanthridines
  • Photosensitizing Agents
  • Viologens
  • Singlet Oxygen
  • Oxygen
Topics
  • DNA, Superhelical (chemistry, drug effects)
  • Intercalating Agents (pharmacology)
  • Oxygen (chemistry)
  • Phenanthridines (pharmacology)
  • Photochemistry
  • Photosensitizing Agents (pharmacology)
  • Plasmids
  • Singlet Oxygen
  • Viologens (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: