1,5-Anhydro-D-glucitol evaluates daily glycemic excursions in well-controlled NIDDM.
Abstract | OBJECTIVE: To evaluate the usefulness of plasma 1,5-anhydro-D-glucitol (1,5-AG) as a possible marker for daily glycemic excursion, we measured plasma 1,5-AG, HbA1c, fasting plasma glucose (FPG) level, and daily excursion of glycemia, from which the M-value (after Schlichtkrull) was calculated as an index of daily glycemic excursion. RESEARCH DESIGN AND METHODS: RESULTS: HbA1c values were similar among all the groups (diet, 6.9 +/- 0.6; OHA, 7.2 +/- 0.5; CIT, 7.1 +/- 0.6; MIT, 7.2 +/- 0.5%). The MIT group showed a significantly higher 1,5-AG concentration (11.5 +/- 5.3 micrograms/ml), a significantly lower M-value (9.2 +/- 5.2), and little risk of hypoglycemia ( < 4 mmol/l) and hyperglycemia ( > 10 mmol/l) (1.3 +/- 1.1 times/24 h) compared with the CIT group (6.9 +/- 3.3 micrograms/ml, 15.7 +/- 8.9, 2.2 +/- 1.6 times/24 h, respectively). Insulin doses (22.4 +/- 4.5 vs. 22.0 +/- 8.9 U/day), FPG (6.6 +/- 2.2 vs. 7.4 +/- 2.4 mmol/l), and HbA1c concentrations were not significantly different between the CIT and MIT groups. M-values significantly correlated with 1,5-AG concentrations (r = 0.414, P < 0.05), but not with HbA1c concentrations. CONCLUSIONS: The findings suggest that the plasma 1,5-AG concentration can be a useful index of the daily excursion of blood glucose, especially in patients with well-controlled NIDDM.
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Authors | M Kishimoto, Y Yamasaki, M Kubota, K Arai, T Morishima, R Kawamori, T Kamada |
Journal | Diabetes care
(Diabetes Care)
Vol. 18
Issue 8
Pg. 1156-9
(Aug 1995)
ISSN: 0149-5992 [Print] United States |
PMID | 7587851
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Biomarkers
- Blood Glucose
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Insulin
- 1,5-anhydroglucitol
- Deoxyglucose
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Topics |
- Biomarkers
(blood)
- Blood Glucose
(metabolism)
- Deoxyglucose
(blood)
- Diabetes Mellitus, Type 2
(blood, diet therapy, drug therapy)
- Diet, Diabetic
- Drug Administration Schedule
- Female
- Glycated Hemoglobin
(analysis)
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Insulin
(administration & dosage, therapeutic use)
- Isomerism
- Male
- Middle Aged
- Regression Analysis
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