Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease.

A high survival rate of grafted dopamine neurons is crucial for reversing neurological deficits following brain tissue transplantation in Parkinson's disease. For unknown reasons the survival rate of transplanted dopamine neurons is only around 10% in experimental animals. The hypothesis that oxidative stress causes the loss of transplanted neurons was tested by grafting neurons from transgenic mice that overexpress Cu/Zn superoxide dismutase. Compared with the survival of those taken from non-transgenic littermates, the survival was 4 times higher for the transgenic dopamine neurons with a concomitant more extensive functional recovery. The results provide direct support for the free radical hypothesis of dopaminergic neuron death in brain tissue grafting.
AuthorsN Nakao, E M Frodl, H Widner, E Carlson, F A Eggerding, C J Epstein, P Brundin
JournalNature medicine (Nat Med) Vol. 1 Issue 3 Pg. 226-31 (Mar 1995) ISSN: 1078-8956 [Print] UNITED STATES
PMID7585038 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Amphetamines
  • RNA, Messenger
  • Superoxide Dismutase
  • Amphetamines (pharmacology)
  • Animals
  • Disease Models, Animal
  • Female
  • Gene Expression
  • Graft Survival
  • Mesencephalon (cytology, embryology, transplantation)
  • Mice
  • Mice, Transgenic
  • Parkinson Disease (therapy)
  • RNA, Messenger (genetics)
  • Rats
  • Rats, Sprague-Dawley
  • Stereotyped Behavior (drug effects)
  • Substantia Nigra (enzymology)
  • Superoxide Dismutase (metabolism)
  • Transplantation, Heterologous

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