Abstract | BACKGROUND: Earlier in vitro studies have suggested that the eosinophil may release its granule proteins selectively depending on the stimulus to which the cell is exposed. OBJECTIVE: METHODS: RESULTS: In acute bacterial infections ECP, but not EPO, was significantly raised in serum (P < 0.0001) compared with non-infected healthy subjects. In acute bacterial infections ECP was significantly correlated to the levels of the neutrophil marker myeloperoxidase (MPO) (rs = 0.96, P < 0.0001) but not to EPO. In acute viral infections neither ECP nor EPO were on average raised. However, almost 20% the patients had elevated levels of bot proteins. In the viral infections the serum-levels of ECP and EPO were correlated (rs = 0.63, P < 0.001), but no correlation was found with MPO. CONCLUSION: It is concluded that eosinophils are activated during acute bacterial infections and that this activation results in the preferential mobilisation of ECP. The simultaneous assay of the two eosinophil proteins, ECP and EPO, may give new insight into the role of the eosinophil in disease.
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Authors | M Karawajczyk, K Pauksen, C G Peterson, E Eklund, P Venge |
Journal | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
(Clin Exp Allergy)
Vol. 25
Issue 8
Pg. 713-9
(Aug 1995)
ISSN: 0954-7894 [Print] England |
PMID | 7584682
(Publication Type: Journal Article)
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Chemical References |
- Blood Proteins
- Eosinophil Granule Proteins
- Eosinophil Peroxidase
- Peroxidases
- Peroxidase
- Ribonucleases
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Topics |
- Acute Disease
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Bacterial Infections
(metabolism)
- Blood Proteins
(metabolism)
- Child
- Eosinophil Granule Proteins
- Eosinophil Peroxidase
- Female
- Humans
- Male
- Middle Aged
- Peroxidase
(blood)
- Peroxidases
(blood)
- Ribonucleases
- Virus Diseases
(metabolism)
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