Modulation of mite antigen-induced immune responses by lecithin-bound iodine in peripheral blood lymphocytes from patients with bronchial asthma.

Abstract

1. Dermatophagoides farinae (Df) mite antigen induced IgE synthesis associated with an imbalance of cytokine production in mite-sensitive patients with bronchial asthma; increased production of interleukin 4 (IL-4), and decreased production of interferon-gamma (IFN-gamma) was specifically induced in these patients' lymphocytes. 2. Lecithin-bound iodine (LBI), with which children with bronchial asthma have been successfully treated in the range of 0.5 to 5 microM, concentrations comparable to LBI blood levels in medicated individuals, modified mite antigen-induced immune responses, thereby decreasing abnormal lymphocyte functions. 3. In Df antigen-driven immune responses, inhibition of IgE generation accompanied by suppression of IL-4 and the recovery of IFN-gamma production was successful when LBI was used in vitro. 4. LBI also acted on normal PBMCs by downregulating the IL-4-induced IgE synthesis, phytohaemagglutin (PHA)- and phorbol myristate acetate (PMA) plus calcium ionophore (CaI)-induced IL-4 secretion, and by upregulating purified protein derivatives (PPD)-induced IFN-gamma production. Therefore, LBI was capable of inhibiting the IgE and IL-4 responses and of enhancing IFN-gamma production both from allergen-stimulated atopic cells and from non-atopic cells appropriately stimulated. 5. The expression of human histocompatibility leukocyte antigen (HLA), class II antigens and intercellular adhesion molecule 1 (ICAM-1) on monocytes, crucial molecules for T cell-monocyte interactions, was not altered by LBI. 6. LBI probably acts as an immunomodulator to ameliorate mite antigen-induced abnormal cell-mediated immune responses in patients with bronchial asthma caused by Df antigen thereby leading to improvement of their clinical status.

• Authors: Y Kawano, T Noma
• Journal: British journal of pharmacology (Br J Pharmacol) Vol. 115 Issue 7 Pg. 1141-8 (Aug 1995) ISSN: 0007-1188 [Print] England
• PMID: 7582536 (Publication Type: Journal Article)

Chemical References

• Antigens
• Antigens, Dermatophagoides
• Glycoproteins
• Histocompatibility Antigens Class II
• Phosphatidylcholines
• Intercellular Adhesion Molecule-1
• Interleukin-4
• lecithin-bound iodine
• Immunoglobulin E
• Interferon-gamma
• Iodine

Topics

• Animals
• Antigens (immunology)
• Antigens, Dermatophagoides
• Asthma (blood, immunology)
• Glycoproteins (immunology)
• Histocompatibility Antigens Class II (immunology)
• Humans
• Immunoglobulin E (biosynthesis)
• Intercellular Adhesion Molecule-1 (immunology)
• Interferon-gamma (biosynthesis)
• Interleukin-4 (metabolism)
• Iodine
• Lymphocytes (immunology)
• Mites (immunology)
• Phosphatidylcholines (pharmacology)