[The effect of antioxidants on functional brain disorders caused by low-intensity ionizing radiation].

Abstract

The effects of daily intraperitoneal injections of alpha-tocopherol (30 mg/kg per day) and synthetic antioxidant IHFAN-30 (30 mg/day) in rats were compared during low-level ionizing radiation (10 days, dose rate 5 mGy/h, total dose 1.2 Gy). There were analysed: (1) amplitude of population spike of hippocampal slices; (2) endogenous phosphorylation in vitro of hippocampal synaptic proteins in the presence of cAMP; (3) formation, manifestation and reduction of food-procuring reflex. The findings showed that antioxidants made some correction of the functional state of hippocampal slices and cAMP-dependent phosphorylation system activity in brain cells from irradiated animals. No influence on training and memory functions was detected.

• Authors: O V Godukhin, V I Arkhipov, T G Shipakina, S V Kalemenev, E B Burlakova
• Journal: Radiatsionnaia biologiia, radioecologiia (Radiats Biol Radioecol) 1995 Jul-Aug Vol. 35 Issue 4 Pg. 500-6 ISSN: 0869-8031 [Print] Russia (Federation)
• Vernacular Title: Issledovanie vliianiia antioksidantov na narusheniia funktsional'noĭ aktivnosti mozga, vyzvannye ioniziruiushchim izlucheniem maloĭ moshchnosti.
• PMID: 7581801 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antioxidants
• IHFAN 30
• Nerve Tissue Proteins
• Organic Chemicals
• Vitamin E

Topics

• Animals
• Antioxidants (therapeutic use)
• Brain (drug effects, physiopathology, radiation effects)
• Conditioning, Classical (drug effects, radiation effects)
• Drug Evaluation, Preclinical
• Evoked Potentials (drug effects, radiation effects)
• Gamma Rays
• Male
• Memory (drug effects, radiation effects)
• Nerve Tissue Proteins (drug effects, metabolism, radiation effects)
• Organic Chemicals
• Phosphorylation (drug effects, radiation effects)
• Radiation Injuries, Experimental (drug therapy, physiopathology)
• Rats
• Synaptic Membranes (drug effects, metabolism, radiation effects)
• Time Factors
• Vitamin E (therapeutic use)