[The effect of the intranigral use of the delta sleep-inducing peptide and its analogs on the motor and seizure activities of rats].

Abstract

The effects of delta-sleep inducing peptide (DSIP) and its analogues (1-4) administered into substantia nigra pars reticulata on locomotor and seizure activity were estimated in experiments in rats. It was shown that intranigral microinjection of DSIP as well as DSIP-1-DSIP-4 caused decreasing of horizontal, vertical locomotor activity and attendance of central sectors of the "open field". Antiseizure effects, i.e. the first and clonic-tonic picrotoxin-induced convulsive latent period lengthening and their intensity decreasing, revealed DSIP, DSIP-2 and DSIP-3. Authors suppose that changes of DSIP structure lead to changes of effects expression on locomotor and seizure activity in conditions of their administration into substantia nigra reticulata. Obtained data concerning protective effects of studied peptides on experimental seizure syndrome allow to conclude that there is interaction between DSIP-induced hypokinesia and DSIP analogues anticonvulsive effectiveness in case of their intranigral administration which is likelihood is one of the component of nigral-dependent seizure-suppressive mechanism.

• Authors: A A Shandra, L S Godlevskiĭ, R S Vast'ianov, A I Brusentsov, I I Mikhaleva, I A Prudchenko, V N Zaporozhan
• Journal: Fiziologicheskii zhurnal imeni I.M. Sechenova (Fiziol Zh Im I M Sechenova) Vol. 81 Issue 2 Pg. 1-6 (Feb 1995) ISSN: 1027-3646 [Print] Russia (Federation)
• Vernacular Title: Vliianie vnutrinigral'nogo primeneniia del'ta-son indutsiruiushchego peptida i ego analogov na dvigatel'nuiu i sudorozhnuiu aktivnost' krys.
• PMID: 7581535 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anticonvulsants
• Picrotoxin
• Delta Sleep-Inducing Peptide

Topics

• Animals
• Anticonvulsants (administration & dosage, pharmacology)
• Delta Sleep-Inducing Peptide (administration & dosage, analogs & derivatives, pharmacology)
• Drug Evaluation, Preclinical
• Male
• Microinjections
• Motor Activity (drug effects, physiology)
• Picrotoxin
• Rats
• Rats, Wistar
• Reaction Time (drug effects, physiology)
• Seizures (chemically induced, drug therapy, physiopathology)
• Substantia Nigra