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Acute hemolysis during cyclosporine therapy successfully treated with vitamin E.

Abstract
The immunosuppressant cyclosporine induces acute hemolysis (hemolytic uremic syndrome) in some patients after transplantation, possibly because of its effects on the vascular endothelium. We report a case of Coombs-negative, non-immune severe hemolytic anemia during cyclosporine therapy after allogeneic bone marrow transplantation for severe aplastic anemia. Uremia was not observed. Vitamin E was effective in treating the intravascular hemolysis.
AuthorsE Azuma, M Hirayama, T Nakano, M Nagai, S Hiratake, Y Komada, M Sakurai
JournalBone marrow transplantation (Bone Marrow Transplant) Vol. 16 Issue 2 Pg. 321-2 (Aug 1995) ISSN: 0268-3369 [Print] England
PMID7581157 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunosuppressive Agents
  • Vitamin E
  • Cyclosporine
Topics
  • Acute Disease
  • Adolescent
  • Anemia, Aplastic (therapy)
  • Anemia, Hemolytic (drug therapy, etiology)
  • Bone Marrow Transplantation (adverse effects)
  • Cyclosporine (adverse effects)
  • Humans
  • Immunosuppressive Agents (adverse effects)
  • Male
  • Vitamin E (therapeutic use)

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