A 49-year-old female presented with a low abdominal
tumor. Before operation, she had neither evidence of
androgen excess nor abnormal
tumor marker values, but US, CT and MRI findings strongly suggested the possibility of a malignant ovarian
tumor. Her operative findings were as follows: a goose egg-sized main
tumor in the low abdomen, with a walnut-sized
tumor in the right side, which grew around the right ureter, causing right non-functional kidney. Pathological examination revealed her
tumor was a very rare type of malignant Sertoli-Leidig cell
tumor with pelvic lymph nodes
metastases. Most patients with this disease usually have good prognoses, but with
metastasis or recurrence, no
therapy is as effective as in
epithelial ovarian cancer. In this case, we selected a new
combination chemotherapy of
CBDCA,
Etoposide and
Epirubicin, considering current changes in the
chemotherapy for ovarian
germ cell tumors and Sertoli-Leidig cell
tumors of testis. Now, 1 year and 4 months after operation, she has no evidence of recurrence or
metastasis. This study proposes a new, presumably more effective
chemotherapy for an ovarian malignant Sertoli-Leidig cell
tumor.