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[Pharmacokinetics of SK & F 104864 in experimental animals. II. Tissue distribution].

Abstract
After intravenous bolus injection of a camptothecin derivative, SK & F 104864 (topotecan), at 20 mg/kg into Sarcoma 180 bearing mice, the tissue concentration of total topotecan (SK & F 104864 plus SK & F 105992) in the mice decreased bi-exponentially, and the beta half-lives in most tissues were longer than those in plasma. The AUCs of total topotecan were extremely large in the kidney, that was followed by the pancreas > intestine > stomach > spleen > liver > thymus > lung > tumor > uterus > plasma. The concentration of total topotecan after 24 hours decreased to less than 2% of the peak level in most tissues except the kidney.
AuthorsH Fujita, M Okamoto, A Takao, H Abe, R Ishii, H Arase
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 22 Issue 12 Pg. 1789-92 (Oct 1995) ISSN: 0385-0684 [Print] Japan
PMID7574811 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Topotecan
  • Camptothecin
Topics
  • Animals
  • Antineoplastic Agents (administration & dosage, pharmacokinetics)
  • Camptothecin (administration & dosage, analogs & derivatives, pharmacokinetics)
  • Female
  • Injections, Intravenous
  • Mice
  • Mice, Inbred ICR
  • Sarcoma 180 (metabolism)
  • Tissue Distribution
  • Topotecan

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