Abstract |
After intravenous bolus injection of a camptothecin derivative, SK & F 104864 ( topotecan), at 20 mg/kg into Sarcoma 180 bearing mice, the tissue concentration of total topotecan (SK & F 104864 plus SK & F 105992) in the mice decreased bi-exponentially, and the beta half-lives in most tissues were longer than those in plasma. The AUCs of total topotecan were extremely large in the kidney, that was followed by the pancreas > intestine > stomach > spleen > liver > thymus > lung > tumor > uterus > plasma. The concentration of total topotecan after 24 hours decreased to less than 2% of the peak level in most tissues except the kidney.
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Authors | H Fujita, M Okamoto, A Takao, H Abe, R Ishii, H Arase |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 22
Issue 12
Pg. 1789-92
(Oct 1995)
ISSN: 0385-0684 [Print] Japan |
PMID | 7574811
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Topotecan
- Camptothecin
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, pharmacokinetics)
- Camptothecin
(administration & dosage, analogs & derivatives, pharmacokinetics)
- Female
- Injections, Intravenous
- Mice
- Mice, Inbred ICR
- Sarcoma 180
(metabolism)
- Tissue Distribution
- Topotecan
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