Abstract | OBJECTIVE: STUDY DESIGN: During an 11-month period 342 women who first attended Chiang Mai University Hospital antenatal clinic at < or = 17 weeks' gestation were randomized to received either oral pyridoxine hydrochloride, 30 mg per day, or placebo in a double-blind fashion. Patients graded the severity of their nausea by a visual analog scale and recorded the number of vomiting episodes over the previous 24 hours before treatment and again during 5 consecutive days on treatment. RESULTS: There was a significant decrease in the mean of posttherapy minus baseline nausea scores in the pyridoxine compared with that in the placebo group (t test, p = 0.0008). There was also a greater reduction in the mean number of vomiting episodes, but the differences did not reach statistical significance (p = 0.0552). CONCLUSION:
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Authors | T Vutyavanich, S Wongtra-ngan, R Ruangsri |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 173
Issue 3 Pt 1
Pg. 881-4
(Sep 1995)
ISSN: 0002-9378 [Print] United States |
PMID | 7573262
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiemetics
- Placebos
- Pyridoxine
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Topics |
- Adult
- Antiemetics
(therapeutic use)
- Double-Blind Method
- Female
- Humans
- Nausea
(drug therapy)
- Placebos
- Pregnancy
- Pregnancy Complications
(drug therapy)
- Pyridoxine
(therapeutic use)
- Vomiting
(drug therapy)
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