Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial.

Abstract

OBJECTIVE:

Our purpose was to determine the effectiveness of pyridoxine for nausea and vomiting of pregnancy.

STUDY DESIGN:

During an 11-month period 342 women who first attended Chiang Mai University Hospital antenatal clinic at < or = 17 weeks' gestation were randomized to received either oral pyridoxine hydrochloride, 30 mg per day, or placebo in a double-blind fashion. Patients graded the severity of their nausea by a visual analog scale and recorded the number of vomiting episodes over the previous 24 hours before treatment and again during 5 consecutive days on treatment.

RESULTS:

There was a significant decrease in the mean of posttherapy minus baseline nausea scores in the pyridoxine compared with that in the placebo group (t test, p = 0.0008). There was also a greater reduction in the mean number of vomiting episodes, but the differences did not reach statistical significance (p = 0.0552).

CONCLUSION:

Pyridoxine is effective in relieving the severity of nausea in early pregnancy.

• Authors: T Vutyavanich, S Wongtra-ngan, R Ruangsri
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 173 Issue 3 Pt 1 Pg. 881-4 (Sep 1995) ISSN: 0002-9378 [Print] United States
• PMID: 7573262 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antiemetics
• Placebos
• Pyridoxine

Topics

• Adult
• Antiemetics (therapeutic use)
• Double-Blind Method
• Female
• Humans
• Nausea (drug therapy)
• Placebos
• Pregnancy
• Pregnancy Complications (drug therapy)
• Pyridoxine (therapeutic use)
• Vomiting (drug therapy)