Closantel intoxication in a dog.

Abstract	A case of overdosage with closantel, a salicynalide derivative, in a dog is described. The dog received 6 times the recommended dosage. Closantel induced optic neuritis, retinal degeneration, partial deafness, hepatotoxicosis and myopathy. Only the blindness was irreversible. The therapy included albumin administration to reduce the acute toxicity of closantel.
Authors	K McEntee, M Grauwels, C Clercx, M Henroteaux
Journal	Veterinary and human toxicology (Vet Hum Toxicol) Vol. 37 Issue 3 Pg. 234-6 (Jun 1995) ISSN: 0145-6296 [Print] United States
PMID	7571353 (Publication Type: Case Reports, Journal Article)
Chemical References	Albumins Anthelmintics Salicylanilides closantel
Topics	Albumins (administration & dosage, therapeutic use) Animals Anthelmintics (administration & dosage, adverse effects, metabolism) Blindness (chemically induced, veterinary) Chemical and Drug Induced Liver Injury Deafness (chemically induced, veterinary) Dog Diseases (chemically induced) Dogs Drug Overdose (veterinary) Follow-Up Studies Liver (drug effects) Liver Diseases (veterinary) Male Optic Neuritis (chemically induced, veterinary) Retinal Degeneration (chemically induced, veterinary) Salicylanilides (administration & dosage, adverse effects, metabolism)

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