Developmental toxicity of the substituted phenylurea herbicide isoproturon in rats.

Abstract

Isoproturon, a substituted phenylurea herbicide, was studied for its toxicity to dams and its potential fetotoxic/teratogenic effects in the fetuses of albino rats. Isoproturon technical administered orally at 45, 90 or 180 mg/kg/d to dams during d 6-20 of pregnancy did not produce maternal toxicity at 45 or 90 mg/kg/d. However, 180 mg isoproturon/kg/d caused changes in maternal enzymes and chromatid breaks. There was no fetotoxic/teratogenic effect of isoproturon at the tested dosage levels in number of implantations, percent resorption, fetal weights, and external, visceral and skeletal fetal observations.

• Authors: M K Srivastava, R B Raizada
• Journal: Veterinary and human toxicology (Vet Hum Toxicol) Vol. 37 Issue 3 Pg. 220-3 (Jun 1995) ISSN: 0145-6296 [Print] United States
• PMID: 7571348 (Publication Type: Journal Article)

Chemical References

• Enzymes
• Herbicides
• Methylurea Compounds
• Phenylurea Compounds
• Teratogens
• Progesterone
• isoproturon

Topics

• Animals
• Brain (drug effects, embryology, pathology)
• Embryonic and Fetal Development (drug effects)
• Enzymes (metabolism)
• Female
• Herbicides (toxicity)
• Kidney (drug effects, pathology)
• Liver (drug effects, embryology, enzymology, pathology)
• Male
• Methylurea Compounds (toxicity)
• Phenylurea Compounds
• Pregnancy
• Progesterone (blood)
• Radioimmunoassay
• Rats
• Rats, Wistar
• Sister Chromatid Exchange (drug effects)
• Teratogens (toxicity)