Chromosome assignments of genes for human Na(+)-dependent phosphate co-transporters NaPi-3 and NPT-1.

Abstract

Chromosome assignments for the genes encoding human renal high affinity Na/phosphate co-transporters NaPi-3 and NPT-1 were derived by analyzing somatic cell hybrid DNAs. Polymerase chain reaction (PCR), using primers specific for two human Na/Pi co-transporters demonstrated that the genes for NaPi-3 was assigned to human chromosome 5 while that for NPT-1 was assigned to human chromosome 6. Renal phosphate transporter genes may be candidates for causing hereditary hypophosphatemia with hypercalciuria in humans.

• Authors: K Miyamoto, S Tatsumi, H Yamamoto, K Katai, Y Taketani, K Morita, E Takeda
• Journal: The Tokushima journal of experimental medicine (Tokushima J Exp Med) Vol. 42 Issue 1-2 Pg. 5-9 (Jul 1995) ISSN: 0040-8875 [Print] Japan
• PMID: 7570593 (Publication Type: Journal Article)

Chemical References

• Carrier Proteins
• SLC17A1 protein, human
• Sodium-Phosphate Cotransporter Proteins
• Sodium-Phosphate Cotransporter Proteins, Type I
• Symporters

Topics

• Base Sequence
• Carrier Proteins (genetics)
• Chromosome Mapping
• Chromosomes, Human, Pair 5
• Chromosomes, Human, Pair 6
• Humans
• Hypophosphatemia, Familial (genetics)
• Kidney (metabolism)
• Molecular Sequence Data
• Sodium-Phosphate Cotransporter Proteins
• Sodium-Phosphate Cotransporter Proteins, Type I
• Symporters