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[Detection of beta-lactamases resistant to inhibitors (IRT) by the disk diffusion method].

AbstractUNLABELLED:
85 E. coli strains producing various beta-lactamase were studied: TEM low level: n = 11, TEM high level: n = 4, oxacillinase (OXA): n = 5, céphalosporinase (CASE) +/- TEM: n = 5, inhibitor resistant TEM (IRT) n = 50, IRT+TEM: n = 3, IRT+
CASE:
n = 7. Their susceptibility to amoxicillin (AMX), amoxicillin+clavulanate (AMC), ticarcillin (TIC), ticarcillin+clavulanate (TCC), piperacillin (PIP), piperacillin+tazobactam (TAZ), mecillinam (MEC), cephalotin (CF), cefoxitin (FOX) et ceftazidime (CAZ) were evaluated by a disk diffusion method, in order to determine the resistance pattern which allows a reliable detection of IRT-producing strains. The phenotype AMX R, TIC R, AMCI/R, TCCI/R et CFS was observed in 46 out of 53 IRT +/- TEM strains, 4/5 of OXA strains and 1/11 of TEM low level strains. A better sensitivity could be obtained by a modification of breakpoints for AMC, TCC and CF, however OXA-producing strains remain indistinguishable from IRT-strains.
AuthorsJ P Romaszko, L Bret, C Henquell, D Sirot, C Chanal, J Sirot
JournalPathologie-biologie (Pathol Biol (Paris)) Vol. 43 Issue 4 Pg. 306-9 (Apr 1995) ISSN: 0369-8114 [Print] France
Vernacular TitleDétection des beta-lactamases résistantes aux inhibiteurs (IRT) par la méthode de diffusion.
PMID7567120 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • beta-Lactams
  • beta-Lactamases
Topics
  • Anti-Bacterial Agents (pharmacology)
  • Bacteriological Techniques
  • Drug Resistance, Microbial
  • Escherichia coli (drug effects, enzymology)
  • Humans
  • In Vitro Techniques
  • beta-Lactamases (metabolism)
  • beta-Lactams

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