Abstract |
Striatal enkephalin-containing neurons receive dopaminergic inputs from the substantia nigra and project to the external segment of globus pallidus. These neurons express primarily dopamine (DA) D-2 receptors. Accordingly, stimulation of enkephalinergic transmission might be expected to influence mainly D-2 receptor agonist or antagonist effects on motor function. To test this hypothesis, the effects of SCH 32615, an enkephalinase inhibitor, on DA antagonist-induced catalepsy, DA D-1 agonist-induced non-stereotyped grooming, and DA D-2 agonist-induced stereotyped behavior were studied. The administration of SCH 32615 (3 mg/kg) decreased both D-1 and D-2 antagonist-induced catalepsy. In contrast, SCH 32615 (0.3 mg/kg) increased D-1 agonist-induced non-stereotyped grooming and D-2 agonist-induced stereotypies. These results suggest that a DA agonist-like, mostly D-2 activity may be involved in enkephalinergic-mediated functions.
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Authors | C Marin, T N Chase |
Journal | Neuropharmacology
(Neuropharmacology)
Vol. 34
Issue 6
Pg. 677-82
(Jun 1995)
ISSN: 0028-3908 [Print] England |
PMID | 7566505
(Publication Type: Journal Article)
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Chemical References |
- Dipeptides
- Protease Inhibitors
- Receptors, Dopamine D1
- Receptors, Dopamine D2
- SCH 32615
- Neprilysin
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Topics |
- Animals
- Behavior, Animal
(drug effects)
- Catalepsy
(chemically induced)
- Dipeptides
(pharmacology)
- Dose-Response Relationship, Drug
- Grooming
- Male
- Motor Activity
(drug effects)
- Neprilysin
(drug effects)
- Protease Inhibitors
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Receptors, Dopamine D1
(drug effects)
- Receptors, Dopamine D2
(drug effects)
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