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Effects of SCH 32615, an enkephalinase inhibitor, on D-1 and D-2 dopamine receptor-mediated behaviors.

Abstract
Striatal enkephalin-containing neurons receive dopaminergic inputs from the substantia nigra and project to the external segment of globus pallidus. These neurons express primarily dopamine (DA) D-2 receptors. Accordingly, stimulation of enkephalinergic transmission might be expected to influence mainly D-2 receptor agonist or antagonist effects on motor function. To test this hypothesis, the effects of SCH 32615, an enkephalinase inhibitor, on DA antagonist-induced catalepsy, DA D-1 agonist-induced non-stereotyped grooming, and DA D-2 agonist-induced stereotyped behavior were studied. The administration of SCH 32615 (3 mg/kg) decreased both D-1 and D-2 antagonist-induced catalepsy. In contrast, SCH 32615 (0.3 mg/kg) increased D-1 agonist-induced non-stereotyped grooming and D-2 agonist-induced stereotypies. These results suggest that a DA agonist-like, mostly D-2 activity may be involved in enkephalinergic-mediated functions.
AuthorsC Marin, T N Chase
JournalNeuropharmacology (Neuropharmacology) Vol. 34 Issue 6 Pg. 677-82 (Jun 1995) ISSN: 0028-3908 [Print] England
PMID7566505 (Publication Type: Journal Article)
Chemical References
  • Dipeptides
  • Protease Inhibitors
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • SCH 32615
  • Neprilysin
Topics
  • Animals
  • Behavior, Animal (drug effects)
  • Catalepsy (chemically induced)
  • Dipeptides (pharmacology)
  • Dose-Response Relationship, Drug
  • Grooming
  • Male
  • Motor Activity (drug effects)
  • Neprilysin (drug effects)
  • Protease Inhibitors (pharmacology)
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Dopamine D1 (drug effects)
  • Receptors, Dopamine D2 (drug effects)

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