Efficacy of 6-amino-2-n-pentylthiobenzothiazole on Trichophyton in vitro and in vivo.

Abstract

In vitro and in vivo antifungal activities of synthetically parepared 6-amino-2-n-pentylthiobenzothiazole (APB) against Trichophyton strains were studied. APB inhibited the growth of 3 Trichophyton strains at 65 micrograms/ml. 2-Mercaptobenzothiazole was not effective at 125 micrograms/ml and ketoconazole inhibited the growth at 20-30 micrograms/ml. Treatment of experimental dermatophytosis in guinea pigs using 2.5% APB cream was studied in comparison to Canesten cream (1% clotrimazole). Dermatophytosis was considerably reduced after both APB and Canesten therapies.

• Authors: H Bujdáková, M Múcková, M Klobusický, E Sidóová
• Journal: Mycopathologia (Mycopathologia) Vol. 130 Issue 3 Pg. 141-5 (Jun 1995) ISSN: 0301-486X [Print] Netherlands
• PMID: 7566067 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antifungal Agents
• Benzothiazoles
• Thiazoles
• captax
• 6-amino-2-n-pentylthiobenzothiazole
• Clotrimazole
• Ketoconazole

Topics

• Animals
• Antifungal Agents (pharmacology, therapeutic use)
• Benzothiazoles
• Clotrimazole (therapeutic use)
• Guinea Pigs
• Ketoconazole (pharmacology)
• Microbial Sensitivity Tests
• Thiazoles (pharmacology, therapeutic use)
• Tinea (drug therapy)
• Trichophyton (drug effects)