Endotoxin-induced liver injury and changes in the levels of plasma tumor necrosis factor-alpha and interleukin-6 in rabbits.

ELISA was employed to detect changes in plasma TNF-alpha and IL-6 level in rabbits having endotoxin-induced generalized Shwartzman reaction. Liver injury was assessed by the increase of serum ALT and hepatic histopathologic changes. The results showed that plasma TNF-alpha and IL-6 levels increased remarkably 12h after intravenous injection of endotoxin twice at a 24h interval, and these changes corresponded with the degree of liver injury. Coinjection of dexamethasone and endotoxin partly prevented the elevation of TNF-alpha and IL-6 levels and reduced liver injury. These results indicated that TNF-alpha and IL-6 were involved in endotoxin-induced liver injury.
AuthorsC Wu, M Li, C Chen, M Zhang
JournalChinese medical journal (Chin Med J (Engl)) Vol. 108 Issue 7 Pg. 548-50 (Jul 1995) ISSN: 0366-6999 [Print] CHINA
PMID7555277 (Publication Type: Journal Article)
Chemical References
  • Endotoxins
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • Animals
  • Drug-Induced Liver Injury
  • Endotoxins
  • Escherichia coli
  • Interleukin-6 (blood)
  • Liver (pathology)
  • Liver Diseases (blood)
  • Male
  • Necrosis
  • Rabbits
  • Tumor Necrosis Factor-alpha (metabolism)

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