HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of a corn diet during development on [3H]-spiperone binding in the brain of rats at the perinatal stage.

Abstract
A model of undernutrition based on feeding with a corn-diet (tryptophan deficient) was used to study maturation and physiology of the rat brain 5-HTergic system. Previously, using that model, we observed a decrease in 5-HT uptake in rat brain slices, assuming that some compensatory mechanisms could be implicated at the synaptic level on those conditions. Body, brain weight, and total [3H]-spiperone binding were recorded at two fetal ages and newborn pups from mothers were fed with a corn-diet and with a corn-lysine diet. Significant decreases in body weight and in [3H]-spiperone binding were observed at all ages studied in the corn-based diet groups with respect to controls at the first postnatal day of age, whereas at the 18th gestation day, the [3H]-spiperone binding was higher in the protein restricted and corn-lysine supplemented group than in the control group. Results suggested that expression of 5-HT receptors and possibly their synthesis may be limited at the synaptic level on undernutrition conditions.
AuthorsC Beas-Zárate, D Ortuño-Sahagún, A R Del Angel Meza, A Feria-Velasco
JournalComparative biochemistry and physiology. Part A, Physiology (Comp Biochem Physiol A Physiol) Vol. 112 Issue 1 Pg. 161-6 (Sep 1995) ISSN: 1096-4940 [Print] United States
PMID7553330 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Tritium
  • Spiperone
Topics
  • Aging (metabolism)
  • Animals
  • Animals, Newborn (growth & development, metabolism)
  • Body Weight
  • Brain (anatomy & histology, embryology, metabolism)
  • Diet
  • Embryonic and Fetal Development
  • Female
  • Fetus (anatomy & histology, metabolism, physiology)
  • Organ Size
  • Rats
  • Rats, Wistar
  • Spiperone (metabolism)
  • Tritium
  • Zea mays

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: