Abstract |
A model of undernutrition based on feeding with a corn-diet ( tryptophan deficient) was used to study maturation and physiology of the rat brain 5-HTergic system. Previously, using that model, we observed a decrease in 5-HT uptake in rat brain slices, assuming that some compensatory mechanisms could be implicated at the synaptic level on those conditions. Body, brain weight, and total [3H]- spiperone binding were recorded at two fetal ages and newborn pups from mothers were fed with a corn-diet and with a corn- lysine diet. Significant decreases in body weight and in [3H]- spiperone binding were observed at all ages studied in the corn-based diet groups with respect to controls at the first postnatal day of age, whereas at the 18th gestation day, the [3H]- spiperone binding was higher in the protein restricted and corn- lysine supplemented group than in the control group. Results suggested that expression of 5-HT receptors and possibly their synthesis may be limited at the synaptic level on undernutrition conditions.
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Authors | C Beas-Zárate, D Ortuño-Sahagún, A R Del Angel Meza, A Feria-Velasco |
Journal | Comparative biochemistry and physiology. Part A, Physiology
(Comp Biochem Physiol A Physiol)
Vol. 112
Issue 1
Pg. 161-6
(Sep 1995)
ISSN: 1096-4940 [Print] United States |
PMID | 7553330
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aging
(metabolism)
- Animals
- Animals, Newborn
(growth & development, metabolism)
- Body Weight
- Brain
(anatomy & histology, embryology, metabolism)
- Diet
- Embryonic and Fetal Development
- Female
- Fetus
(anatomy & histology, metabolism, physiology)
- Organ Size
- Rats
- Rats, Wistar
- Spiperone
(metabolism)
- Tritium
- Zea mays
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