Abstract | OBJECTIVE: To determine whether the use of gemeprost is associated with histological changes in the second trimester fetus. SETTING: Histopathology department of a university hospital. DESIGN: Retrospective comparison of histological features in fetuses aborted following maternal administration of gemeprost, with those in fetuses after spontaneous miscarriage. OUTCOME MEASURES: Degree of tissue fragmentation; other histological abnormalities. RESULTS: Significantly greater fragmentation of the liver was found in fetuses exposed to gemeprost (P = 0.046). Nonsignificant effects were found for brain (P = 0.082) and heart (P = 0.183), and no effect was seen on the kidney, adrenal and lung. No other significant histological differences were found between the two groups. CONCLUSIONS: This study is the first to document an effect of gemeprost on the fetus, but confirmation is required in further studies. Other implications are discussed.
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Authors | E J Lazda, V R Sams |
Journal | British journal of obstetrics and gynaecology
(Br J Obstet Gynaecol)
Vol. 102
Issue 9
Pg. 731-4
(Sep 1995)
ISSN: 0306-5456 [Print] England |
PMID | 7547765
(Publication Type: Journal Article)
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Chemical References |
- Abortifacient Agents, Nonsteroidal
- gemeprost
- Alprostadil
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Topics |
- Abortifacient Agents, Nonsteroidal
(pharmacology)
- Alprostadil
(analogs & derivatives, pharmacology)
- Autolysis
- Female
- Fetus
(drug effects, pathology)
- Humans
- Male
- Pregnancy
- Pregnancy Trimester, Second
- Retrospective Studies
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