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Sensing starvation: a homoserine lactone--dependent signaling pathway in Escherichia coli.

Abstract
When nutrients become limiting, many bacteria differentiate and become resistant to environmental stresses. For Escherichia coli, this process is mediated by the sigma s subunit of RNA polymerase. Expression of sigma s was induced by homoserine lactone, a metabolite synthesized from intermediates in threonine biosynthesis. Homoserine lactone-dependent synthesis of sigma s was prevented by overexpression of a newly identified protein, RspA. The function of homoserine lactone derivatives in many cell density-dependent phenomena and the similarity of RspA to a Streptomyces ambofaciens protein suggest that synthesis of homoserine lactone may be a general signal of starvation.
AuthorsG W Huisman, R Kolter
JournalScience (New York, N.Y.) (Science) Vol. 265 Issue 5171 Pg. 537-9 (Jul 22 1994) ISSN: 0036-8075 [Print] United States
PMID7545940 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Bacterial Proteins
  • Sigma Factor
  • sigma factor KatF protein, Bacteria
  • homoserine lactone
  • Catalase
  • 4-Butyrolactone
Topics
  • 4-Butyrolactone (analogs & derivatives, metabolism, pharmacology)
  • Amino Acid Sequence
  • Bacterial Proteins (biosynthesis, chemistry, genetics, metabolism)
  • Catalase (metabolism)
  • Escherichia coli (genetics, metabolism)
  • Gene Expression Regulation, Bacterial
  • Models, Biological
  • Molecular Sequence Data
  • Operon
  • Phenotype
  • Sigma Factor (biosynthesis, genetics)
  • Signal Transduction
  • Transcription, Genetic
  • Vibrio (genetics)

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